| 细胞凋亡、肿瘤血管生成及PCNA在膀胱移行细胞癌的表达及其预后意义 |
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| 引用本文： | 张东青,程继义,许纯孝.细胞凋亡、肿瘤血管生成及PCNA在膀胱移行细胞癌的表达及其预后意义[J].山东大学学报(医学版),2001,39(1):18-20. |
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| 作者姓名： | 张东青 程继义 许纯孝 |
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| 作者单位： | 1. 山东大学第二医院泌尿外科
2. 山东省立医院泌尿外科 |
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| 摘 要： | 目的探讨细胞凋亡、肿瘤血管生成及增殖细胞核抗原(PCNA)表达与膀胱移行细胞癌(简称膀胱癌)分级、分期及预后的关系。方法采用DNA末端标记法(TUNEL)和免疫组化法检测53例膀胱癌组织中细胞凋亡指数(AI)、微血管密度(MVD)、PCNA标记指数(PCNALI)，分析其与膀胱癌分级、分期的关系。结果AI与PCNALI在膀胱癌不同分级之间均有显著性差异，MVD在Gl、G3间和G2、G3间差异有显著性；PCNAU在膀胱癌不同分期之间均有显著性差异，而AI与MvD均在T1、T3间和T2、T3间有显著性差异。在复发的膀胱癌中三项指标均高于未复发者。结论AI、MVD、PCNALI可作为评估膀胱癌恶性程度及预后的指标。
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| 关 键 词： | 凋亡 肿瘤血管生成 增殖细胞核抗原 膀胱肿瘤 |
| 文章编号： | 1000-0496(2001)01-0018-03 |
| 修稿时间： | 2000年3月23日 |
STUDY OF APOPTOSIS, ANGIOGENESIS AND EXPRESSION OF PCNA IN BLADDER TRANSITIONAL CELL CARCINOMA |
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| ZHANG Dong-qing,CHENG Ji-yi,XU Chun-xiao.STUDY OF APOPTOSIS, ANGIOGENESIS AND EXPRESSION OF PCNA IN BLADDER TRANSITIONAL CELL CARCINOMA[J].Journal of Shandong University:Health Sciences,2001,39(1):18-20. |
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| Authors: | ZHANG Dong-qing CHENG Ji-yi XU Chun-xiao |
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| Abstract: | Objective:To study the correlation among apoptosis,angiogenesis,expression of PCNA and bladder transitional cell carcinoma.Methods:AI,MVD,PCNALI were detected by means of TUNEL and S ABC immunohistochemical technique.Results:All of AI,MVD,PCNALI elevated respectively with tumor grades and stages,statistical differences were observed between G1 and G2,G2 and G3 in AI,MVD or PCNALI except for between G1 and G2 in MVD;or between T1 and T2,T2 and T3 in PCNALI;or between T1 and T3,T2 and T3 in AI,MVD.AI,MVD and PCNALI in recurrent tumors prone to recur were higher than those in non recurrent tumors.Conclusion:AI,MVD and PCNALI were claimed to be valuable in biological activities of bladder cancer. |
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| Keywords: | Apoptosis Angiogenesis Proliferating cell nuclear antigen Bladder neoplasms |
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