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| 偏头痛患者血浆内皮素与环核苷酸水平变化研究 | |
| 引用本文： | 宋成忠,李义召,夏作理,张东君,王世华,邓小梅.偏头痛患者血浆内皮素与环核苷酸水平变化研究[J].山东大学学报(医学版),2003,41(4):421-422. |
| 作者姓名： | 宋成忠 李义召 夏作理 张东君 王世华 邓小梅 |
| 作者单位： | 1. 济南长城医院 2. 山东大学齐鲁医院 3. 泰山医学院 |
| 摘 要： | 目的:观察偏头痛患者发作期与间歇期血浆内皮素与环苷酸水平的变化,探讨其变化在偏头痛发生与发展中的作用。方法:选择80例偏头痛患者,用放免法检测血浆内皮素(ET)、环腺苷酸(cAMP)、环鸟苷酸(cGMP)水平的变化。结果:偏头痛患者发作期ET、cAMP水平显著高于对照组及间歇期水平(P<0.05P<0.01);偏头痛发作期cGMP水平明显低于对照组及偏头痛间歇期水平(P<0.05)。结论:偏头痛发作期ETcAMP与cGMP水平变化可能参与了偏头痛的发作过程。 |
| 关 键 词： | 偏头痛 内皮素 环腺苷酸 环鸟苷酸 |
| 文章编号： | 1671-7554(2003)04-0421-02 |
| 修稿时间： | 2002年12月30 |
Changes of endothelium, cyclic adenosine monophosphate and cyclic guanosine monophosphate of plasma in patients with migraine |
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| SONG Cheng-zhong,LI Yi-zhao,XIA Zuo-li,et al.Changes of endothelium, cyclic adenosine monophosphate and cyclic guanosine monophosphate of plasma in patients with migraine[J].Journal of Shandong University:Health Sciences,2003,41(4):421-422. | |
| Authors: | SONG Cheng-zhong LI Yi-zhao XIA Zuo-li |
| Institution: | Jinan Great Wall Hospital |
| Abstract: | Objective:To observe the changes of endothelium(ET),cyclic adenosine monophosphate(cAMP)and cyclic guanosine monophosphate(cGMP)of plasma in patients with migraine during attack and headache-free interval,and to explore the effects of the changes in the outbreak of migraine.Methods:Radioimmuno-assay was used to measure the levels of plasma ET,cAMP and cGMP in80patients with migraine and30healthy controls.Results:The levels of ET and cAMP were remarkedly increased,but the level of cGMP in plasma was remarkedly reduced in the migraine group during attack than those in the control group and the migraine group during headache-free interval.Conclusion:The level changes of plasma ET,cAMP and cGMP during attack might be related to the outbreak of acute migraine. |
| Keywords: | Migraine Endothelium Cyclic adenosine monophosphate Cyclic guanosine monophos-phate |
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