转化生长因子β1与高血压靶器官损害的关系

目的：探讨血清转化生长因子β1 （TGFβ1）与原发性高血压（EH）靶器官损害之间的关系及其作用机制。方法：82例EH患者，按照尿白蛋白／肌酐比（albumin-to-creatinine ratio, ACR）分为3组：ACR≥300mg/g为临床蛋白尿组（A组，28例）；30mg/g＜ACR＜300mg/g为微量蛋白尿组（B组，31例）；ACR≤30mg/g为无蛋白尿组（C组，23例）。采用双抗体夹心ELISA法测定空腹血清转化生长因子β1(TGFβ1)，放射性免疫分析法测定血浆血管紧张素Ⅱ(AngⅡ)水平及尿ACR；应用超声心动图测定并计算左室重量指数（LVMI）。比较3组间上述指标的差异性，分析EH组TGFβ1与LVMI、ACR和AngⅡ的相关性。结果：血清TGFβ1水平A组明显高于B组和C组（P＜0.01）,B组和C组比较差异有统计学意义（P＜0.05）。相关分析表明，EH患者血清TGFβ1水平与血浆ACR、AngⅡ、LVMI呈正相关（P＜0.05～0.01）。结论：TGFβ1在原发性高血压心肾靶器官损害的发生发展过程中起重要作用。

Correlation between TGF-β1 and hypertensive target organ damage

Objective： To investigate the relationship between the serum level of TGFβ1 and hypertensive target organ damage in patients with essential hypertension(EH). Methods： Eighty-two patients with EH were enrolled and divided into three groups based on the albumin-to-creatinine ratio (ACR): a group with ACR≥300mg/g (group A, n=28), a group with ACR＞30mg/g＜300mg/g (group B, n=31), and a group with ACR≤30mg/g (group C, n=23). Levels of ACR and AngⅡwere determined by radioimmunoassay, and serum TGFβ1 by a sandwich ELISA. The left ventricular telediastolic internal diameter, interventricular septum diastolic, posterior wall thickness, left ventricular mass index and left ventricular ejection fraction were determined by M B mode echocardiography. Results： TGFβ1 level was significantly higher in group A than in groups B and C(P＜0.01), and was also significantly different between group B and C(P＜0.05). TGFβ1 was directly related to ACR，AngⅡ and LVMI, but not related to BMI or blood pressure. Conclusion： TGFβ1, a useful marker plays an important role in the occurrence and progression of hypertensive target organ damage.