青少年上颌快速扩弓对龈沟液中AST活性影响的研究

目的：观察上颌快速扩弓前后龈沟液中天冬氨酸转氨酶(AST)活性的变化，研究AST与上颌快速扩弓牙周组织改建的关系。方法：选择43例上颌快速扩弓患者，10.2～12.5岁，分为对照组（21例）和加力组（22例）。利用全自动化生化分析仪检测快速扩弓前、快速扩弓24h后、1周、2周、3周、4周龈沟液中AST活性的变化，用酶总量/30s表示。结果：加力组AST水平在快速扩弓24h开始升高，至4周后一直维持在较高水平，且与对照组存在差异。结论: 龈沟液中AST的活性可以在一定程度上反映上颌快速扩弓牙周组织的改建。

Effect of rapid palatal expansion on AST activities in gingival crevicular fluid in adolescents

Objective: To study the relationship between aspartate aminotransferase (AST) activities and periodontal tissue remodeling during rapid palatal expansion in adolescents. Methods: Forty-three patients (aged 10.2-12.5 years) were divided into two groups: the control group(21 cases) and the experimental group(22 cases). GCF samples were collected with filter paper strips at 6 time points: before activation, 24 hours, the first week, the second week, the third week, and the fourth week after activation. AST activities were determined by full automatic biochemical analysis. The results were expressed as total AST activities (μU/30s). Results: AST activities were significantly elevated at 24 hours after activation by the Haas appliance, and remained at a high level until the fourth week after activation. Moreover, from 24 hour after activation to the fourth week after activation, AST activities in the experimental group significantly increased. Conclusion: The results suggest that AST activities in GCF reflect the tissues remodeling which occurs in the periodontium to some degree during rapid palatal expansion.