| 自体CIK细胞治疗对卵巢癌调节性T细胞的影响 |
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| 引用本文： | 于渊,李岩,荣风年,梁婧,刘晓琳,王福立.自体CIK细胞治疗对卵巢癌调节性T细胞的影响[J].山东大学学报(医学版),2010,48(5):101-104. |
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| 作者姓名： | 于渊 李岩 荣风年 梁婧 刘晓琳 王福立 |
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| 作者单位： | 1. 山东大学附属千佛山医院,肿瘤科,济南,250014
2. 山东大学附属千佛山医院,妇产科,济南,250014 |
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| 基金项目： | 山东省自然科学基金资助课题(2008ZRB02001) |
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| 摘 要： | 目的 观察细胞因子激活的杀伤细胞（CIK）对卵巢癌患者外周血CD4+CD25+调节性T细胞及T细胞亚群变化的影响。方法 对30例经病理确诊为卵巢癌的患者,取其自体外周血单个核细胞,通过培养将其诱导为CIK细胞,然后将细胞进行自体回输。2周后采用流式细胞仪检测外周血CD4+CD25+调节性T细胞、T细胞亚群及NK细胞的变化。结果 CIK细胞输注后,患者外周血CD4+CD25+调节性T细胞减少(P＜0.01),CD8+下降(P＜0.05),CD3+、CD4+细胞、CD4+/CD8+比值及NK细胞较治疗前显著升高。结论 卵巢癌患者经自体CIK细胞回输治疗后,外周血调节性T细胞的数量降低,T细胞亚群比例失调和功能低下的状况得到不同程度的改善。
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| 关 键 词： | 调节性T细胞 CIK细胞 免疫治疗 卵巢肿瘤 |
| 收稿时间： | 2010-01-13 |
Therapy effect of auto-CIK on regulatory T cells in ovarian neoplasm patients |
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| YU Yuan,LI Yan,RONG Feng-nian,LIANG Jing,LIU Xiao-lin,WANG Fu-li.Therapy effect of auto-CIK on regulatory T cells in ovarian neoplasm patients[J].Journal of Shandong University:Health Sciences,2010,48(5):101-104. |
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| Authors: | YU Yuan LI Yan RONG Feng-nian LIANG Jing LIU Xiao-lin WANG Fu-li |
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| Institution: | YU Yuan1,LI Yan1,RONG Feng-nian2,LIANG Jing1,LIU Xiao-lin1,WANG Fu-li1(1.Department of Oncology,2.Department of Gynaecology , Obstetrics Qianfoshan Hospital of Sh,ong University,Jinan 250014,China) |
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| Abstract: | Objective To evaluate the variation of CD4+CD25+ regulatory T cells and T cell subsets affected by cytokine-induced killer cells in ovarian neoplasm patients.Methods Thirty ovarian neoplasm patients pathologically diagnosed were collected.The auto-CIK cells were transfused back into patients after peripheral blood was cultured and induced into CIK cells.The levels of CD4+CD25+ regulatory T cells,T cell subsets and NK cells were detected with flow cytometry two weeks later.Results CD4+CD25+ regulatory T cell... |
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| Keywords: | Regulatory T cells Cytokine induced killer cells Immunotherapy Ovarian neoplasm |
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