小儿血液细菌培养及药敏分析

目的了解近1年我院血培养检出菌的分布特点以及药物敏感情况,以利于临床合理使用抗生素。方法归纳我院2003-07~2004-06血培养检出菌559株。应用BACT-9120全自动血培养系统,API鉴定系统。药敏试验采用M-H琼脂纸片扩散(K-B)法。结果凝固酶阴性葡萄球菌(CNS)检出构成比居于首位,占45.26%;金黄色葡萄球菌位于第三位,占6.08%;易产生耐药性的肠球菌和微球菌分居第四、六位,各占4.29%3、.40%。检出常见的G+菌对抗生素敏感性依次排为:万古霉素、头孢哌酮、头孢唑啉、磷霉素、头孢曲松。常见G-菌对抗生素的敏感性依次为:头孢哌酮、磷霉素、头孢唑啉、拉氧头孢、丁胺卡那。且复数菌败血症呈上升趋势占30.24%。结论(1)目前小儿血培养检出菌以G+菌居于主导地位,占88.01%;(2)CNS的检出居于首位;(3)低毒力条件致病菌成为当前儿科常见致病菌;(4)小儿检出菌的耐药率较高,治疗需以药物监测为依据。

Analysis on Detected Bacteria and Drug Sensitivity of Hemoculture in Children

Objective To study the distribution of detected bacteria and drug sensitivity in recent one year in order to use the antibiotics reasonably.Methods There were 559 strains of detected bacteria in hemoculture from July 2003 to June 2004 with BACTEC-9120 Autoanalyzer,API and M-H agar scrip diffusion method.Results The CN-S was(45.26%) detected and SA was 6.08%,drug-resistance enterococcus and micrococcus were 4th and 6th in 4.29% and(3.40%.) The drug of detected gram positive bacteria sensitive to were vancomycin,cefaperazone,cefazolin,fosfomycin,and ceftriaxone.The septicaemia with multibacteria trended increase 30.2%.Conclusion The gram positive bacteria was main detected spectrum and CN-S was the first.The low virulence conditional pathogenic bacteria was common.The treatment of antibiotics should be taken and monitored according to the detected results.