|
|||||
|
|
| 老年糖尿病肾病血小板活化分子检测的意义 | |
| 引用本文： | 徐宜英,孙文学,彭武建,戴勇,李富荣,王新根.老年糖尿病肾病血小板活化分子检测的意义[J].黑龙江医学,2004,28(1):26-28. |
| 作者姓名： | 徐宜英 孙文学 彭武建 戴勇 李富荣 王新根 |
| 作者单位： | 1. 深圳市人民医院,暨南大学第二附属医院,老年医学研究所,广东,深圳,518020 2. 深圳市人民医院肾内科,广东,深圳,518020 3. 深圳市人民医院临床医学研究中心,广东,深圳,518020 |
| 摘 要： | 目的 通过检测血小板活化时表达的特异膜糖蛋白分子 ,以探讨老年糖尿病肾病时血小板的活化状态及其临床意义。方法 利用流式细胞仪 (FCM)检测 35例老年糖尿病肾病患者及 2 4例正常人外周血血小板的膜糖蛋白CD 6 2P ,CD 6 3,CD 4 1,CD 6 1的表达。结果 老年糖尿病肾病组的CD 6 2P ,CD 6 3表达与正常对照组比较均显著增高 (P <0 0 0 1) ,同时老年糖尿病肾病组的CD 4 1,CD 6 1表达与正常人组比较差异没有显著性 (P >0 0 5 )。结论 老年糖尿病肾病患者的血小板活化增强 ,因此检测血小板活化分子的特异膜糖蛋白在老年糖尿病肾病中有重要的临床应用价值。 |
| 关 键 词： | 内科学 血小板活化 老年糖尿病肾病 流式细胞分析法 CD62P CD63 CD41 CD61 |
| 文章编号： | 1004-5775(2004)01-0026-03 |
| 修稿时间： | 2003年12月20 |
Significance of Detection of Platelet Activation Markers in Elderly Diabetic Nephropathy |
|
| XU Yi-ying,SUN Wen-xue,PENG Wu-jian,et al..Significance of Detection of Platelet Activation Markers in Elderly Diabetic Nephropathy[J].Heilongjiang Medical Journal,2004,28(1):26-28. | |
| Authors: | XU Yi-ying SUN Wen-xue PENG Wu-jian |
| Abstract: | Objective To evaluate active platelet status in elderly diabetic nephropathy and its clinical significance by detection of activated platelet membrane glycoprotein. Methods In 35 elderly patients with diabetic nephropathy and 24 normal controls, the expression level of peripheral platelet membrane glycoprotein CD 62P, CD 63, CD 41 and CD 61 were measured by flow cytometry. Results The expression levels of CD 62P and CD 63 on platelet in group of elderly patients were no significant difference as compared to normal control (P>0.05). Conclusion The platelet activity increases in elderly patient with diabetic nephropathy. Detection of activated platelet membrane glycoprotein in them had an important clinical value. |
| Keywords: | Internal medicine Platelet activation Elderly diabetic nephropathy Flow cytometry CD 62P CD 63 CD 41 CD 61 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |