宫颈癌患者年轻化与人乳头瘤病毒感染增加的关系

目的探讨人乳头状瘤病毒感染与宫颈鳞状细胞癌发病年龄的关系。方法分析1999-01～2006-12在我院住院治疗的120例宫颈鳞癌患者的发病年龄，并对其肿瘤组织进行了HPV16E7检测。结果宫颈鳞状细胞癌患者平均发病年龄逐渐减小；HPV16的感染率由25．00％上升到51．56％。年轻宫颈鳞癌患者HPV16的感染率（86．59％）明显高于年龄较大者（31．00％）（P〈0．01）。结论随着HPV16感染率的升高，宫颈鳞癌患者年轻化趋势愈明显，HPV16感染与宫颈鳞状细胞癌年轻化有关。因此，对HPV感染的高危人群应加强监测、随访，做到早诊断、早治疗。

Clinical Analysis on the Relationship Between Human Papillomavirus Infection and the Age of Patients with Cervical Carcinoma

Objective To investigate the relationship between the human papillomavirus infections and the ages of patients with cervical carcinoma.Methods The HPV16E7 was detected by immunohistochemistry in 120 patients of cervical carcinoma from 1999 to 2006 and the ages of them were analysed.Results The ages of the patients gradually became younger from 1999 to 2006;the incidence of HPV16 infection in 2003～2006 was 51.56%,which was significantly higher than 25.00% in 1999～2002(P<0.05).The incidence of HPV16 infections in young women whose age was less than 40 was 86.59%,which was significantly higher than 31.00% in older women(P<0.01).Conclusion The age of cervical carcinoma tends to be young,which is associated with HPV16 infections.The monitoring of HPV infection is important for prevention and early diagnosis of cervical carcinoma in high-risk population.