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2型糖尿病患者血清白介素-18肿瘤坏死因子-α与胰岛素抵抗的相关性研究
引用本文:汪玲,郑绍同,陈敏.2型糖尿病患者血清白介素-18肿瘤坏死因子-α与胰岛素抵抗的相关性研究[J].黑龙江医学,2006,30(10):735-737.
作者姓名:汪玲  郑绍同  陈敏
作者单位:南京医科大学附属淮安第一医院,江苏,淮安,223300
摘    要:目的探讨2型糖尿病患者的血清白介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)与胰岛素抵抗(IR)的关系。方法选择62例2型糖尿病患者和40例正常对照组,测定各组空腹血清IL-18、TNF-α水平,同时检测空腹血糖(FPG)、胰岛素(FINS)、血脂,测量身高、体重、腰围、臀围计算体重指数(BMI)、腰臀比(WHR),采用HOMA-IR模型公式计算胰岛素抵抗指数。结果2型糖尿病患者的血清IL-18、TNF-α、FPG、FINS及HOMA-IR水平显著高于对照组(P<0.01),经相关性分析IL-18水平与BMI和WHR呈正相关,血清IL-18、TNF-α均与HOMA-IR呈正相关。结论IL-18、TNF-α是糖尿病患者IR的独立影响因素,2型糖尿病患者血浆IL-18、TNF-α水平升高可间接反映胰岛素抵抗程度。

关 键 词:IL-18  TNF-α  2型糖尿病  胰岛素抵抗
文章编号:1004-5775(2006)10-0735-03
收稿时间:08 28 2006 12:00AM
修稿时间:2006年8月28日

Study of Association Between Serum Interleukin-18,TNF-αand Insulin Resistance in type 2 Diabetes Mellitus
WANG Ling,ZHENG Shao-tong,CHEN Min.Study of Association Between Serum Interleukin-18,TNF-αand Insulin Resistance in type 2 Diabetes Mellitus[J].Heilongjiang Medical Journal,2006,30(10):735-737.
Authors:WANG Ling  ZHENG Shao-tong  CHEN Min
Institution:The Affiliated Huaian First Hospetal of Najing Medical Uniuersity, Huaian 223300, China
Abstract:Objective To assess the assouation of serum Interliukin-18,TNF-α and insulin resistance in type 2 diabetes mellitus.Methods 62 T2DM patients and 40 non-diabetic controls were selected levels of Interliukin-18,TNF-α meal measured.Fasting blood glucose and fasting insulin,blood lvpid,BMI and WHR were measured.Homa-IR were calculated.Results The levels of serum Interliukin-18,TNF-α and Homa-IR in T2DM group were significantly higher than those in control group.IL-18 and TNF-α level of serum was positively corrdated with Homa-IR.IL-18 level of serum was positively associated with BMI and WHR.Conclusion IL-18,TNF-α independent risk foctors for IR may be involved in T2DM development,and it could reflect the degree of insulin resistance indirectly.
Keywords:Interliukin-18  TNF-α  Type 2 diabetes mellitus  Insulin resistance
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