| 卡莫司汀长循环热敏脂质体的制备与表征 |
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| 引用本文： | 张明宇,曾昭武,.卡莫司汀长循环热敏脂质体的制备与表征[J].中国医学工程,2008(3). |
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| 作者姓名： | 张明宇 曾昭武 |
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| 作者单位： | 中南大学湘雅医院神经外科;中南大学生物医学工程研究院; |
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| 摘 要： | 目的研究卡莫司汀长循环热敏脂质体的制备及表征。方法采用薄膜分散并超声法制备卡莫司汀长循环热敏脂质体,采用透射电镜、激光粒度分析仪检测其形态与粒径分布,采用凝胶柱层析法分离脂质体与游离药物,采用高效液相色谱法研究其含量与包封率。结果卡莫司汀长循环热敏脂质体粒径约100nm左右,包封率达97%以上。结论成功制备了卡莫司汀长循环热敏脂质体。
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| 关 键 词： | 卡莫司汀 长循环热敏脂质体 高效液相色谱 |
Preparation and characteristics of carmustine long-circulating thermosensitive liposomes |
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| ZHANG Ming-yu,ZENG Zhao-wu.Preparation and characteristics of carmustine long-circulating thermosensitive liposomes[J].China Medical Engineering,2008(3). |
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| Authors: | ZHANG Ming-yu ZENG Zhao-wu |
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| Institution: | ZHANG Ming-yu1,ZENG Zhao-wu2(1.Department of neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410005,2.Institute of Biomedical Engineering of Central South University,Hunan 410008,P.R.China) |
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| Abstract: | 【Objective】Preparation and characteristic of Carmustine long-circulating thermosensitive liposomes are studied.【Methods】Carmustine long-circulating thermosensitive liposomes was prepared by file dispersing-ul-trasound,Its shape and size distribution were detected by transmission electron microscope(TEM) and Zetasizer,liposomes and free drug were separated by gel column chromatography,and its content and entrapped efficiency(EE%) were detected by HPLC.【Results】The sizes of Carmustine long-circulating thermos... |
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| Keywords: | carmustine long-circulating thermosensitive liposomes HPLC |
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