| 壳聚糖在组织工程中的应用 |
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| 引用本文： | 孔祥烨,郑静,王晓军,李星熠,傅少志,李沐纯,钱志勇,.壳聚糖在组织工程中的应用[J].中国医学工程,2009(3):185-188. |
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| 作者姓名： | 孔祥烨 郑静 王晓军 李星熠 傅少志 李沐纯 钱志勇 |
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| 作者单位： | [1]四川大学华西医院生物治疗国家重点实验室,四川成都610041 [2]成都信息工程学院图书馆,四川成都610225 [3]西藏气象局科技减处,西藏拉萨850000 [4]中南大学生物医学工程研究院,湖南长沙410008 |
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| 基金项目： | 国家863项目（2007AA021902）,国家自然科学基金项目（NSFC20704027）,博士点基金项目（SRFDP200806100065）以及四川省杰出青年科技基金项目（07ZQ026-033）资助. |
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| 摘 要： | 壳聚糖是甲壳素脱乙酰化后的产物,具有良好的生物相容性和生物可降解性,并且具有低毒、无免疫原性等特点。作为自然界唯一的天然阳离子多糖并且拥有良好的生物学性质,使得壳聚糖在药学、医学、组织工程等领域的研究备受关注。近年来,壳聚糖及其衍生物材料作为天然高分子组织工程支架越来越受到重视。本文综述了壳聚糖及其衍生物在不同器官（骨、软骨、皮肤、肝等）组织工程中的研究现状。
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| 关 键 词： | 壳聚糖 组织工程 支架材料 |
Application of chitosan in tissue engineering |
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| KONG Xiangye,ZHENG Jing,WANG Xiaojun,LI Xingyi,FU Shaozhi,LI Muehun,QIAN Zhiyong.Application of chitosan in tissue engineering[J].China Medical Engineering,2009(3):185-188. |
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| Authors: | KONG Xiangye ZHENG Jing WANG Xiaojun LI Xingyi FU Shaozhi LI Muehun QIAN Zhiyong |
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| Institution: | 1.State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuaug 610041, P.R.China; 2.Library of Chengdu University of Information Technology, Chengdu, Sichuang 610225, P.R. China; 3.Division of Science and Technology for Disaster Reduction,Bureau of Meteorology of Tibet, Lasha, Xizhang 850000, P.R.China; 4.1nstitute of Biomedical Engineering, Central South University, Changsha, Hunan 410008, P.R.China) |
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| Abstract: | Chitosan, deacetylation product of chitin, has good biocompatibility, biodegradability, low toxicity, non-immunogenicity, etc. As the only natural cationic polysaccharide, chitosan has gained considerable interest in the field of pharmacy, medicine and tissue engineering because of its favorable biological properties. In recent years, chitosan and its derivates have drawn more and more attentions as the natural polymer scaffold in the application of tissue engineering. In the present paper, we reviewed the application of chitosan and its derivates in the tissue engineering of different organs （bone, cartilage, skin, liver, and etc.）. |
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| Keywords: | chitosan tissue engineering scaffold material |
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