| 大黄对严重烧伤大鼠肠黏膜屏障保护作用的实验研究 |
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| 引用本文： | 徐晓燕,王红梅,应颖,徐方云.大黄对严重烧伤大鼠肠黏膜屏障保护作用的实验研究[J].江西医学院学报,2008,48(1):16-18,F0004. |
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| 作者姓名： | 徐晓燕 王红梅 应颖 徐方云 |
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| 作者单位： | [1]江西省消防总队医院烧伤科,南昌330009 [2]南昌大学医学院病理生理教研室,南昌330006 |
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| 摘 要： | 目的探讨大黄对严重烧伤大鼠肠黏膜屏障的保护作用。方法将36只SD大鼠随机分为对照组（n=6）、烧伤组（n=15）和大黄治疗组（n=15）。对照组不作任何处理；烧伤组和大黄治疗组均于背部造成30％TBSAⅢ度烫伤（以下称烧伤）创面，伤后立即经腹腔补充乳酸林格液（40mL／kg），大黄治疗组大鼠伤后通过灌胃给予大黄混悬液（60mg／kg）治疗。检测各组大鼠伤后72h的血浆内毒素含量，取肠系膜淋巴结（MLN）、肝、脾组织匀浆后进行细菌培养，对空肠黏膜组织进行病理形态学分析。结果血浆内毒素含量大黄治疗组〈对照组〈烧伤组；肠系膜淋巴结、肝、脾组织匀浆细菌移位量大黄治疗组〈烧伤组；空肠黏膜组织病理形态学观察发现，大黄治疗组较烧伤组绒毛上皮细胞水肿减轻，绒毛被覆上皮比较完整，绒毛顶端上皮细胞坏死、脱落减少。结论大黄能减轻严重烧伤引起的肠黏膜损伤，可减少肠源性感染的发生。
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| 关 键 词： | 大黄 烧伤 肠黏膜屏障 动物 实验 大鼠 |
| 文章编号： | 1000-2294（2008）01-0016-03 |
| 收稿时间： | 2007-08-30 |
| 修稿时间： | 2007年8月30日 |
An Experimental Study on Protective Effect of Rhubarb on Intestinal Mucosal Barrier in Rats with Serve Burns |
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| XU Xiao-yan,WANG Hong-mei,YING Ying,XU Fang-yun.An Experimental Study on Protective Effect of Rhubarb on Intestinal Mucosal Barrier in Rats with Serve Burns[J].Acta Academiae Medicinae Jiangxi,2008,48(1):16-18,F0004. |
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| Authors: | XU Xiao-yan WANG Hong-mei YING Ying XU Fang-yun |
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| Institution: | XU Xiao-yan1,WANG Hong-mei2,YING Ying2,XU Fang-yun2(1.Department of Burn,Jiangxi Fire-man Hospital,Nanchang 330009,China,2.Department of Pathophysiology,Nanchang UniversityMedical College,Nanchang 330006,China) |
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| Abstract: | Objective To explore the protective effect of rhubarb on intestinal mucosal barrier in rats with severe burns.Methods The rats were randomly divided into control group(n=6,without treatment),burn group(n=15,with 30% TBSA full-thickness burn on the back)and rhubarb group(n=15,fed with rhubarb after burns).The rats in the groups with burn injury were resuscitated with intraperitoneal isotonic saline after burned.At 72 hours after burned,the concentration of endotoxin in plasma of all rats was detected and the... |
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| Keywords: | rhubarb burn intestinal mucosal barrier animal experiment rat |
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