| cyclinE、P27、Ki-67蛋白在大肠癌中的表达及意义 |
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| 引用本文： | 易建中,张才全,谢元才,邓小红,方传发.cyclinE、P27、Ki-67蛋白在大肠癌中的表达及意义[J].江西医学院学报,2009,49(6):25-28,33,F0004. |
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| 作者姓名： | 易建中 张才全 谢元才 邓小红 方传发 |
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| 作者单位： | 易建中,谢元才,邓小红,方传发(赣州市人民医院腹部外科,江西,赣州,341000);张才全(重庆医科大学附属第一医院普外科,重庆,400016) |
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| 摘 要： | 目的探讨细胞周期调控因子蛋白表达在大肠癌发生、发展中的作用及对预后的影响。方法采用免疫组化染色对64例大肠癌和12例正常大肠黏膜eyclinE、P27、Ki-67进行检测。结果大肠癌与正常大肠黏膜相比cy-clinE、Ki-67阳性表达率明显增高，P27阳性表达率明显降低（均P〈0．05）。Duke’s A期cyclinE阳性表达率明显高于Duke’s B、C、D期（P〈O．05），无淋巴结转移明显高于有淋巴结转移者（P〈0．05）；cyclin E的表达与大肠癌患者的预后无关。P27表达下降或缺乏．与大肠癌的Duke’s分期、淋巴结转移有关（P〈0．05），且其5年生存率显著降低（P〈0．05）。Ki-67表达与大肠癌部位，Duke’s分期及患者预后无关。绪论eyelinE过表达及P27蛋白表达下降或缺失可能会加速细胞周期的转化，并参与大肠癌的发生；eycinE过表达可能是大肠癌形成过程中较早的分子事件。P27蛋白表达下降或缺失可能促进了大肠癌的发展及转移，且提示为患者预后不良的危险因素。
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| 关 键 词： | 大肠癌 cyclin E P27 Ki-67 细胞周期 预后 |
Expression of cyclinE, P27 and Ki-67 in Colorectal Carcinoma Cells and the Significance |
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| Institution: | YI Jian-zhong , ZHANG Cai-quan, XIE Yuan-cai , DENG Xiao-hong , FANG Chuan-fa (1. Department of Abdominal Surgery, the People＇s Hospital of Ganzhou , Ganzhou 341000, China ; 2. Department of General Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China) |
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| Abstract: | Objective To explore the effect of the expression of cell cycle regulators on the development and prognosis of colorectal carcinoma. Methods The expressions of cyclinE and P27 and Ki-67 were detected with immunohistochemical staining in the large intestine mucosa from 64 cases of carcinoma and 12 samples of normal mucosa. Results The positive rates of cyclinE and P27 and Ki-67 were significalntly higher in colorectal carcinoma than in normal mucosa （P〈 0.05）. The expression of cyclinE in Duke＇s stage A was markedly higher than in Duke＇s stage B, C and D （P〈0. 05）,and it was higher in cases of negative lymph node metastasis than those of positive lymph node metastasis （P〈0.05）. The expression of cyclinE had nothing to do with the prognosis of the cases of lymph node metastasis. The expression＇s decline or deficiency of P27 was related to advanced Duke＇s stages （P〈0.05） and lymph node metastasis （P〈0.05）. Ki-67 expression was not associated with the carcinoma localization,advanced Duke＇s stages and prognosis. Conclusion The overexpression of cyclinE and decline or deficiency of P27 expression might accelerate the progression of the cell cycle and promote the carcinogenesis of colorectal carcinoma. The overexpression of cyclinE might be a relatively early event in initiation of colorectal carcinoma. The decline or deficiency of P27 expression might promote the development and metastasis of colorectal carcinoma, and it could be an indicator for unfavorable prognosis. |
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| Keywords: | cyclin E P27 Ki-67 colorectal carcinoma cyclin E P27 Ki-67 cell cycle prognosis |
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