2型糖尿病甲状腺功能及甲状腺自身抗体的评价

目的分析2型糖尿病患者甲状腺功能变化和自身抗体水平。方法化学发光法对78例2型糖尿病患者以及74例正常对照组血清FT3、FT4、TSH、aTPO、aTG进行检测分析。结果2型糖尿病甲状腺功能异常者占19．23％。其中15．38％表现为甲状腺功能减退，发生率显著高于正常对照组（P〈0．05）；3．85％的患者表现为甲状腺功能亢进，与正常对照组比较无明显差异（P〉0．05）。2型糖尿病患者aTPO阳性率为52．56％，与正常对照组比较有极显著差异（P〈0．01）；aTG阳性率16．67％，与正常对照组比较统计学差异不明显（P〉0．05）。结论2型糖尿病患者甲状腺功能异常发生率较高，主要表现为甲状腺功能减低和甲状腺自身抗体aTPO的增高，对2型糖尿病患者定期随访甲状腺功能很有必要。

Evaluation of Thyroid Function and Thyroid Autoantibody in Type 2 Diabetes Patients

Objective To evaluate thyroid function and thyroid autoantibody in type 2 diabetes patients. Methods Serum levels of FT3, FT4, TSH, aTPO and aTG were detected of 78 patients with type 2 diabetes and of 74 normal subjects （control）. Results Thyroid dysfunction occurred in 19. 23% of type 2 diabetes patients, of whom 15.38% were hypothyroidism and 3.85% were hyperthyroidism. The positive rates of aTPO and aTG were 52. 56% and 16. 67%. The positive rates of hypothyroidism and aTPO were significantly higher than those of normal control （P〈0. 05）, while the positive rates of hyperthyroidism and aTG had no significant difference with those of normal control. Conclusion Patients with type 2 diabetes are prone to thyroid dysfunction, especially to hypothyroidism. Thyroid autoantibody aTPO was more sensitive than aTG. It is important to monitor thyroid function and thyroid autoantibody for the patients with type 2 diabetes.