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氩氦刀治疗恶性黑色素瘤对小鼠T细胞免疫的影响
引用本文:骆益宙,钱建新,顾小强,于观贞,王战,武清,王杰军. 氩氦刀治疗恶性黑色素瘤对小鼠T细胞免疫的影响[J]. 华南国防医学杂志, 2008, 22(1): 7-8
作者姓名:骆益宙  钱建新  顾小强  于观贞  王战  武清  王杰军
作者单位:解放军454医院肿瘤科,南京,210002;上海长征医院肿瘤科
基金项目:南京军区医药卫生科研项目
摘    要:目的 研究氩氦刀治疗小鼠恶性黑色素瘤后激活特异性T淋巴细胞的免疫效应。方法12只C57/BL小鼠分3组,A组4只接种B16恶性黑色素瘤细胞,并行氩氦刀治疗;B组4只建立荷瘤模型;C组4只为对照。利用混合淋巴细胞反应检测特异性细胞毒性T淋巴细胞的增殖。结果氩氦刀治疗后可显著刺激特异性T淋巴细胞增殖,与对照组比较具有显著性差异(P〈O.01)。结论氩氦刀治疗可有效激活小鼠肿瘤抗原特异性的T细胞。

关 键 词:恶性黑色素瘤  氦刀  T细胞免疫
收稿时间:2007-11-02
修稿时间:2007-11-20

Effect of Cryosurgery on Function of T Cellular Immunity in Mice with Malignant Melanoma Carcinoma
LUO Yi-zhou, QIAN J ian-xin , GU Xiao-qiang ,. Effect of Cryosurgery on Function of T Cellular Immunity in Mice with Malignant Melanoma Carcinoma[J]. Military Medical Journal of South China, 2008, 22(1): 7-8
Authors:LUO Yi-zhou   QIAN J ian-xin    GU Xiao-qiang   
Affiliation:LUO Yi-zhou, QIAN J ian-xin , GU Xiao-qiang , (et al. Department of Oncology , No. 454 Hospital of PLA , Nan- jing Jiangsu 220002, China)
Abstract:Objective To study the effect of cryosurgery on activating T ell immunity in mice with malignant melanoma carcinoma. Methods Twelve C57/BL mice were randomly divided into group A (the mice were transplanted with B16 malignant melanoma cells, then treated by cryosurgery), group B (only transplanted with B16 cells)and group C as control. The proliferative activities of cytotoxic T lymphocytes were investigated by using mixed lymphocytes reaction. Results After cryosurgery, the cytotoxic T lymphocytes were activated into proliferate effectively. The proliferation rate of cytotoxic T lymphocytes in group A was significantly higher than that in group C (P〈O. 01). Conclusion Cryosurgery can effectively activate tumor antigen-specific T lymphocytes.
Keywords:Malignant melanoma  Crvosurgerv   T cell immunity
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