首页 | 本学科首页   官方微博 | 高级检索  
检索        

盐酸黄连素增加肾移植患者环孢霉素A血浓度的临床研究
引用本文:李罄,吴笑春,辛华雯,余爱荣,仲明远,唐礼功,谢森,冷金华,蒋兆健.盐酸黄连素增加肾移植患者环孢霉素A血浓度的临床研究[J].华南国防医学杂志,2001,15(1):7-9.
作者姓名:李罄  吴笑春  辛华雯  余爱荣  仲明远  唐礼功  谢森  冷金华  蒋兆健
作者单位:广州军区武汉总医院
摘    要:目的:研究盐酸黄连素(Berberin hydrochloride,Ber)增加肾移植受者环孢素A(Cyclosporin A,CsA)血浓度的作用。方法:33名服用CsA+Ber患者为试验组,27名单服CsA患者为对照组,以CsA全血浓度作为临床评价指标。结果:合用Ber患者CsA全血浓度与合用前比较增幅达66.9%,与对照组比较亦有显著性提高(P<0.001),停用Ber后CsA全血浓度明显下降。结论Ber能明显升高肾移植受者CsA血浓度。在升高CsA血浓度的同时,Ber并不增加CsA的毒性反应。Ber与CsA合用有望成为一种节省CsA费用的方法。

关 键 词:肾移植  环孢霉素A  血药浓度  盐酸黄连素
修稿时间:2000年7月15日

Clinical study on increased blood concentration of cyclosporin A by berberin hydrochloride in renal transplanted recipients
LI Qing,WU Xiaochun,XIN Huawen,et al..Clinical study on increased blood concentration of cyclosporin A by berberin hydrochloride in renal transplanted recipients[J].Military Medical Journal of South China,2001,15(1):7-9.
Authors:LI Qing  WU Xiaochun  XIN Huawen  
Institution:LI Qing,WU Xiaochun,XIN Huawen,et al. Department of clinical pharmacology,Wuhan General Hospital,Guangzhou,Military Command,Wuhan 430070
Abstract:Objective To study the effect of berberin hydrochloride (Ber) on the elevation of blood concentration of cyclos-porin A (CsA) in renal transplanted recipients. Methods 33 cases with renal transplantation in experimental group were treated with CsA and Ber and 27 cases with renal transplantation in control group received CsA only. Blood levels of CsA, biochemistry indexes for liver and renal function were determined. Results Blood concentrations of CsA in patients combined with Ber went up by 66.9% compared with those before taking Ber and had a significant increase compared with control group. Blood concentrations of CsA were significantly decreased after stopping Ber administration. Conclusion Ber could markedly elevate the blood concentration of CsA in renal transplanted recipients and didn't increase the toxicity of CsA. Ber combined with CsA can be used as a method for saving money on CsA.
Keywords:Renal transplantation Cyclosporin A Drug concentration in blood Berberin Hydrochloride
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号