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长期HBV携带者HBsAg和rHBcAg诱导的抗体表达
引用本文:贾战生,张银霞,等.长期HBV携带者HBsAg和rHBcAg诱导的抗体表达[J].甘肃医药,1995,14(1):10-12.
作者姓名:贾战生  张银霞
作者单位:兰州军区总医院实验科 (贾战生,张银霞,于兰,莫逢琼,吕同德),兰州军区总医院实验科(杨霄鹏)
摘    要:本文研究了36例长期HBV携带者PBMC,在体外应用HBsAg和rBHcAg诱导特异体抗体的产生。结果表明:(1)长期HBV携带者中有61%的患者也可产生抗-HBs,其含量与正常对照组比明显低下(P<0.01),导致抗0-HBs低下的原因可能与过量抗原的抑制,免疫细胞水平的耐受或细胞因子网络平衡失调有关。(2)rHBcAg可以诱导PBMC产生抗-HBc,财时亦可诱导抗-HBc,同时亦可诱导抗-HBe的产生,这可能由于HBcAg和HBeAg在细胞识 水平存在交叉反应。

关 键 词:乙型肝炎病毒  抗体  表面抗原

Production of anti-HBV antibodies of PBMC from long-term HBV carriers in- duced by HBsAg and rHBcAg.
Authors:Jia Zhan- sheng  
Institution:Jia Zhan- sheng,et al.The Department of Experiment,General Hospital of Lanzhou Command. Lanzhou 730050
Abstract:36 cases of long-term hepatitis B virus (HBV) carriers were selectively studied, in which production of anti-HBV antibodies of PBMC from them was induced by HBsAg and HBcAg. The results showed that; (1) 61% long-term HBV carriers produced anti-HBs, but levels of anti-HBs of them were lower than that of normal controls (P< 0.01). The reasons of leading to decrease of anti-HBs were completely unknowed, might involve in the presence of an excess of circulating antigen, tolerance of immune-cells (B or Th) and irregulation of cytokinesis or receptors network balance. (2)Recom-binant HBcAg could induce the production of anti-HBc by PBMC, and also stimulate production of anti-HBe, which might base on the cross-reaction at level of cellular rec-ognization.
Keywords:Hepatitis B virus  long-term carriers  HBsAg  rHBcAg  antibodies
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