宫颈腺癌15例临床病理分析

目的：探讨宫颈腺癌的临床病理特点及鉴别诊断。方法：回顾成都市第一人民医院病理科2012年5月-2014年5月35 923例组织学标本中诊断的15例宫颈腺癌,结合免疫组化分析。结果：在35 923例组织学标本中,诊断宫颈腺癌15例,占0.04%。15宫颈腺癌中,原发性宫颈腺癌8例,占53%。继发性宫颈腺癌7例,占47%。原发性宫颈腺癌组织学亚型包括：宫颈性腺癌5例,子宫内膜样腺癌2例,绒毛管状腺型1例;继发性宫颈腺癌包括：肠型腺癌2例及子宫内膜样腺癌5例,其免疫组化染色ER（＋）、Vim（＋）、CEA 3例（-）,2例灶性（＋）。结论：与宫颈鳞癌相比,宫颈腺癌少见,不易早期发现。临床及免疫组化在宫颈腺癌原发性及继发性的鉴别中有重要意义。

Cervical Adenocarcinoma:A Clinicopathologic Investigation of 15 Cases

Objective：To investigate the clinicopathologic characteristics,diagnosis and differential diagnosis of cervical adenocarcinoma.Methods：Clinicopathologic and immunohistochemical data of 15 cases of endocervical adenocarcinoma,diagnosed among 35 923 patients at Chengdu NO.1people＇s hospital pathology department during May 2012 and May2014were retrospectively reviewed.Results：The prevalence of cervical adenocarcinoma was 15 of 35 923（0.04%）.Among 15 cervical adenocarcinomas,the primary and the secondary tumors were 8（53%）and 7（47%）,respectively.Histopathologically,the subtype of primary cervical adenocarcinomas were of mucinous endocervical type 5cases,of endometrioid type 2cases,and of villoglandular type 1case.The secondary cervical adenocarcinomas comprised intestinal type 2cases and endometrioid type 5cases,in which both ER and Vim staining were positive,and CEA staining was negative in 3cases and focally positive in 2cases.Conclusion：Compared with cervical squamous carcinoma,adenocarcinoma is uncommon,with difficulties in early detection.Clinic and immunohistochemical data are useful for distinguishing primary from secondary cervical adenocarcinoma.