HBV携带产妇血清、乳汁HBV-DNA载量状态与实施母乳喂养安全性的研究

目的：探讨HBV携带产妇血清、乳汁HBV-DNA载量的不同状况与实施母乳喂养安全性的关系.方法：检测产妇血清、乳汁及婴儿血标本HBV-DNA载量.对母乳和人工两种喂养方式婴儿做追踪观察.结果：HBsAg、HBeAg双阳性产妇的血清、乳汁HBV-DNA阳性率分别为100%、49.45%（P＜0.01）.两种喂养方式婴儿的HBV感染率为15.63%和13.56%,无显著性差异;婴儿抗-HBs检测,母乳组抗体几何平均滴度（GMT）明显高于人工喂养组;结论：HBV携带产妇乳汁HBV-DNA阳性率和病毒载量明显低于血清.母乳喂养不影响母婴传播阻断效果,且有助于提高婴儿抗-HBs的GMT水平.

Relationship between hepatitis B virus DNA load in serum and breast milk of HBV carrier mother and the safety of breast feeding

Objective: To investigate the relationship between hepatitis B virus (HBV) DNA load in serum and breast milk of HBV carrier mother and the safety of breast feeding. Methods: The load levels of HBV DNA in the serum and breast milk of HBV carrier mothers (positive for both HBsAg and HBeAg) and in the blood specimens of their infants was detected. The infants received either breast or artificial feeding were followed up. Results: There was significant difference in the positive rate of HBV DNA between the serum and breast milk of HBV carrier mothers (100% vs. 49.45%, P <0.01). No significant difference in HBV infection rate was found between infants received breast feeding and those received artificial feeding (15.63% vs. 13.56%, P >0.05). The geometric mean titer (GMT) of anti-HBs in infants received breast feeding was significantly higher than that in infants received artificial feeding. Conclusion: The positive rate and load level of HBV DNA in breast milk are lower than those in serum in HBV carrier mothers. The breast feeding does not influence the blocking effect of HBV mother-infant transmission and is helpful in increasing the GMT of anti -HBs in the blood of infants.