c-myc基因与胆管癌关系的研究

目的:探讨c-myc基因与胆管癌的关系.方法:原位杂交方法检测c-myc mRNA在30例胆管癌中的表达,同期胰头癌切除之胆管10例做正常对照.结果:c-myc mRNA在胆管癌中的表达率为53.3%,对照组中无表达,差异极显著(P＜0.01).c-myc mRNA阳性率与胆管癌细胞分化程度、原发癌的浸润程度、淋巴结转移有关.结论:c-myc基因与胆管癌的发生、发展密切相关,有望成为与胆管癌有关的一项生物学指标.

Overexpression and significance of c-myc gene in biliary tract cancer

Objective: To study the relation between c-myc gene and biliary tract cancer. Methods:We determined the expression of c-myc gene in 30 cases of biliary tract cancer by using in situ hybridizations. Ten sections of normal biliary tract was used as control.Results:The positive rate of overexpression of c-myc gene in biliary tract cancer was 53.3%,and no expression was found in the 10 cases of normal biliary tract(P<0.01).The positive rate of overexpression of c-myc gene was related to the degree of cell differentiation, the invading degree of primary cancer, the transfer of lymph node. Conclusion:The overexpression of c-myc gene was related to the pathogenesis and development of biliary tract cancer. It may become an important biological index about biliary tract cancer.