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白细胞介素8、弹性蛋白酶与中、重度慢性牙周炎临床指标的相关性
引用本文:王宏岩,潘亚萍,林莉. 白细胞介素8、弹性蛋白酶与中、重度慢性牙周炎临床指标的相关性[J]. 中国医科大学学报, 2007, 36(4): 440-441
作者姓名:王宏岩  潘亚萍  林莉
作者单位:中国医科大学附属口腔医院牙周科,辽宁,沈阳,110002
基金项目:国家科技攻关计划;辽宁省自然科学基金
摘    要:目的:探讨中、重度慢性牙周炎患者龈沟液中白细胞介素8(IL-8)及细胞内、外弹性蛋白酶浓度与临床指标的相关性。方法:检查30名中、重度慢性牙周炎患者初诊和治疗后1个月的牙周临床指标,并检测其龈沟液中IL-8及细胞内、外弹性蛋白酶浓度,以20名牙周健康者作为对照。结果:患病组细胞外弹性蛋白酶浓度显著高于健康对照组(P<0.01)。慢性牙周炎患者龈沟液中细胞外弹性蛋白酶浓度与牙周袋深度、牙周附着丧失呈显著正相关(P<0.01),细胞内、外弹性蛋白酶浓度与牙龈指数呈显著正相关(P<0.01)。结论:细胞外弹性蛋白酶浓度较IL-8浓度更能够反映牙周袋内的炎症程度。

关 键 词:白细胞介素8  弹性蛋白酶  慢性牙周炎
文章编号:0258-4646(2007)04-0440-02
修稿时间:2006-10-17

Correlation between the concentrations of interleukin-8 and elastase and the clinical indexes in patients with moderate to severe periodontitis
WANG Hong-yan,PAN Ya-ping,LIN Li. Correlation between the concentrations of interleukin-8 and elastase and the clinical indexes in patients with moderate to severe periodontitis[J]. Journal of China Medical University, 2007, 36(4): 440-441
Authors:WANG Hong-yan  PAN Ya-ping  LIN Li
Affiliation:Department of Periodontitis,The Affiliated Stomatological Hospital,China Medical University,Shenyang 110002,China
Abstract:Objective:To explore the correlation between the concentrations of interleukin-8 (IL-8) and elastase in the gingival cervicular fluid (GCF) and the clinical indexes in patients with moderate to severe periodontitis. Methods: The periodontal indexes in 30 patients with periodontitis were detected with Florida probe at the baseline and 1 month after the treatment. The levels of IL-8,elastase in the supernatant (EA-s),and elastase in the pellet (EA-p) were measured in these 30 patients with peridontitis and 20 healthy controls. Results: The concentration of EA-s in patients with peridontitis was significantly higher than that in healthy controls. In patients with peridontitis,the concentration of EA-s in GCF was positively correlated with the periodontal pocket depth and attachment loss (P < 0.01),and the concentrations of EA-s and EA-p were positively correlated with gingival indexes (P < 0.01). Conclusion: The concentration of EA-s is more accurate than the concentration of IL-8 for indicating the inflammation of periodontal pocket.
Keywords:interleukin-8  elastase  chronic periodontitis
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