| 应用抗肿瘤McAb3D5和抗CEA McAb对肺癌的免疫组化研究 |
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| 引用本文： | 薛宜,何安光.应用抗肿瘤McAb3D5和抗CEA McAb对肺癌的免疫组化研究[J].中国医科大学学报,1990,19(6):414-418. |
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| 作者姓名： | 薛宜 何安光 |
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| 作者单位： | 中国医科大学肿瘤研究所肺癌研究室
(薛宜，何安光，张宝庚，杨志山)，中国医科大学肿瘤研究所肺癌研究室(汤天趵) |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 应用抗肿瘤单克隆抗体McAb 3D5和抗CEA单克隆抗体,对101例肺癌手术切除标本,作免疫组织化学研究。结果表明,抗肿瘤单克隆抗体McAb 3D5可与63.4%的肺癌标本反应,且对肺鳞癌有较高的阳性率。抗CEA单克隆抗体可与77.2%的肺癌起反应,特别对肺腺癌有较高的阳性率。两种单克隆抗体不具相同抗原性,联合应用时可提高阳性率。
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| 关 键 词： | 单克隆抗体 肺癌 免疫组织化学 |
IMMUNCHISTOCHEMICAL ANALYSIS OF HUMAN PULMCNARY CARCINOMA:USING ANTI-TUMOR MONCCLCNAL ANTIBODY 3D5 AND ANTI-CEA MONOCLONAL ANTIBODY |
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| Xue Yi,et al Cancer Institute.IMMUNCHISTOCHEMICAL ANALYSIS OF HUMAN PULMCNARY CARCINOMA:USING ANTI-TUMOR MONCCLCNAL ANTIBODY 3D5 AND ANTI-CEA MONOCLONAL ANTIBODY[J].Journal of China Medical University,1990,19(6):414-418. |
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| Authors: | Xue Yi Cancer Institute |
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| Abstract: | To evaluate the application of Anti-tumer McAb 3D5, in the conventionalspecimens,a total 101 cases of pulmonary carcinoma were studied with immunohisto-chemical method and compared with Anti-CEA McAb. McAb3D5 immunoreactedwith 64 of 101 cases(63.4%)and was more sensitive for the squamous cell type. Littlestaining were found in adjacent tissues, showing its highly specitivity for lungcancer. The antigen appears in cytoplasm and/or nucleus of tumer cells. Anti-CEA McAb immunoreacted with 78 of 101 cases(77.2 %), and some of adjacentblonchial epithelial were also weekly stained. The result concluded that theMcAb3D5 have specitivity to lung cancer and the antigen recognized by it isdifferent from CEA. Combined detection of McAb3D5 with Anti-CEA McAbelevated the resitive rate in pulmonary carcinoma. |
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| Keywords: | anti-tumor (McAb) immunohistochemistry lung cancer carcino-embryonie antigen (CEA) |
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