普萘洛尔对映体对点燃的作用及机制

目的 研究普萘洛尔对映体对点燃的作用及机制.方法 建立大鼠杏仁核电刺激点燃和戊四唑（PTZ）化学性点燃模型,并建立耗竭GABA诱发的小鼠氨基脲惊厥模型,观察普萘洛尔对映体对点燃和惊厥的影响.结果 左旋体普萘洛尔腹腔注射有抗PTZ点燃作用,降低Ono＇s分级和6级发作百分率（P〈0.01）,在杏仁核点燃模型能降低Racine分级和发作百分率（P〈0.01）,在氨基脲诱发的惊厥模型,左旋体可抑制惊厥（P〈0.01）;右旋体普萘洛尔无抗点燃和惊厥作用.结论 左旋体普萘洛尔有抗点燃作用,其可能通过阻断β-受体抑制点燃发作.

Mechanism and effects of the enantiomer of chrial medicine Propranolol on kindling

Objective： To study the mechalnism and effects of the enantiomer of chrial medicine Propranolol on kin- dling. Methods ： The pentylenetetrazo （ FIZ ） chemical kindling and amydala electrical kindling models in rats were estab- lished while the mice semicarbazide convulsion models which were induced by depletion of GABA were constituted. The in- fluence of Propranolol enantiormer on the kindling and convulsion were observed. Results： The laevorctatory form of Prop- ranolol had antikindling effect in the PTZ kindling rats and reduced the Ono＇ s stage and the percentage of VI stage seizure （P 〈 0.01 ）. In amygdala kindling model Racine＇ s stage and the percentage of seize were also reduced （ P 〈 0.01 ）. The laevorotatory form could inhibit the convulsion on the model induced by semicarbazide（ P 〈 0.01 ）. The dextrorotary form of Propranolol didn＇ t show antikindling and convulsive actions. Conclusion： The mechanism of Propranolol inhibits the seize of kindling may be by blocking 13 - adrenoceptor.