| 2,3-吲哚醌对小鼠PD模型黑质BAX基因表达影响 |
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| 引用本文： | 张芳,宋丽萍,朱秀丽,张继国,岳旺.2,3-吲哚醌对小鼠PD模型黑质BAX基因表达影响[J].泰山医学院学报,2011,32(2):88-90. |
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| 作者姓名： | 张芳 宋丽萍 朱秀丽 张继国 岳旺 |
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| 作者单位： | 1. 青岛大学医学院药理学教研室,山东青岛,266021
2. 泰山医学院药理学教研室,山东,泰安,271016 |
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| 摘 要： | 目的探讨2,3吲哚醌（isatin,ISA）对MPTP制备的C57BL/6J小鼠帕金森病（PD）模型黑质中BAX基因表达影响。方法 C57BL/6J小鼠随机分为五组,空白对照组,MPTP损伤组,ISA低（50 mg/kg,ig）、中（100 mg/kg,ig）、高剂量（200 mg/kg,ig）预处理＋MPTP组。结果与对照组相比,MPTP损伤的小鼠黑质中BAX免疫反应阳性表达增加（P〈0.01）;在ISA 100 mg/kg和200 mg/kg预处理组与MPTP损伤组相比,黑质中BAX免疫反应阳性表达显著降低（P〈0.05）。结论表明ISA对MPTP造成的PD小鼠有明显的保护作用。
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| 关 键 词： | 2 3吲哚醌 MPTP BAX 小鼠 |
Effects of isatin on substantia nigra BAX gene expression in MPTP-induced PD model in mice |
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| ZHANG Fang,SONG Li-ping,ZHU Xiu-li,Yue Wang,ZHANG Ji-guo.Effects of isatin on substantia nigra BAX gene expression in MPTP-induced PD model in mice[J].Journal of Taishan Medical College,2011,32(2):88-90. |
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| Authors: | ZHANG Fang SONG Li-ping ZHU Xiu-li Yue Wang ZHANG Ji-guo |
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| Institution: | ZHANG Fang1 SONG Li-ping1 ZHU Xiu-1i1 Yue Wang1 ZHANG Ji-guo2(1.Qingdao Medical College of Qingdao University,Qingdao 266021,China,2.Taishan Medical College,Taian 271000,China) |
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| Abstract: | Objective:To explore the effect of isatin on substantia nigra(SN) BAX gene expression in MPTP-induced PD model in mice.Methods:C57BL/6J mice were divided into 5 groups:① control group;② MPTP group;③ ISA 50 mg/kg ig + MPTP group;④ ISA 100 mg/kg ig + MPTP group;and ⑤ ISA 200 mg/kg ig + MPTP group.Then immunohistochemical techniques was used to observe the BAX gene’s expression in substantia nigra in each mouse.Results:The results showed that compared with the control group,the BAX immunoreactive expression in SN was higher in MPTP injury mice(P<0.01);in ISA 100 mg / kg and 200 mg / kg pretreatment group,the BAX immunoreactive expression in SN was significantly reduced compared with the MPTP injury group(P<0.05).Conclusion:It is shown that the ISA has the protective effect on MPTP-induced PD model in mice. |
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| Keywords: | MPTP BAX |
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