| 环孢菌素A生理药物动力学模型的参数估计 |
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| 引用本文： | 陈小全,周秀艳,左之利. 环孢菌素A生理药物动力学模型的参数估计[J]. 泰山医学院学报, 2002, 23(4): 337-339 |
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| 作者姓名： | 陈小全 周秀艳 左之利 |
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| 作者单位： | 1. 泰山医学院工程学院,山东,泰安,271000
2. 四川大学化工学院,四川,成都,610065 |
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| 摘 要： | 目的：在建立的哺乳动物整体生理药物动力学模型的基础上，导出了生理药物动力学模型参数（分配系数R，排泄速率常数KE；代谢速率常数KM）的计算公式。方法：并用此公式计算出了大鼠静脉注射环孢菌素A后的各器官或组织的分配系数。结果：本研究的计算方法可以计算出相应的数据。结论：本研究的参数估计方法可客观地计算出分配系数及药物动力学数据。
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| 关 键 词： | 环孢菌素A 生理药物动力学模型 参数估计 |
| 文章编号： | 7115-7115(2002)04-0337-03 |
| 修稿时间： | 2002-06-14 |
Parameter estimation of physiologically based pharmacokinetics model of cyclosporin A |
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| CHEN Xiao-quan ,ZHOU Xiu-yan ZUO Zhi-li. Parameter estimation of physiologically based pharmacokinetics model of cyclosporin A[J]. Journal of Taishan Medical College, 2002, 23(4): 337-339 |
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| Authors: | CHEN Xiao-quan ZHOU Xiu-yan ZUO Zhi-li |
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| Affiliation: | CHEN Xiao-quan 1,ZHOU Xiu-yan 2 ZUO Zhi-li 2 |
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| Abstract: | Objective: To estimate the parameters (distribution coefficient, metabolic velocity constant and elimination velocity constant) based on the general physiologically based pharmacokinetics(PBPK). Methods: Based on the general physiologicallly based pharmacokinetics(PBPK) model for animals and those parameters, the distribution coefficients for the rats that had been injected by vein were estimated. Results: The method produced the relevant data. Conclusion: The method can be used objectively to evaluate the parameters and the coefficients. |
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| Keywords: | physiologically based pharmacokinetics model parameter estimation cyclosporin A |
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