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肿瘤相关成纤维细胞的来源和分子机制
引用本文:张辉,;范跃祖,;王金泗,;林孟波.肿瘤相关成纤维细胞的来源和分子机制[J].中国医学文摘:外科学分册英文版,2014(1):1-7.
作者姓名:张辉  ;范跃祖  ;王金泗  ;林孟波
作者单位:[1]福建省立医院肿瘤外科,福州350001; [2]同济大学附属同济医院外科,上海200065
基金项目:国家自然科学基金项目(81372614)
摘    要:肿瘤相关成纤维细胞(CAFs)不仅在细胞外基质的沉积,而且在肿瘤的生长、进展和转移中发挥重要作用.正常成纤维细胞、上皮细胞,内皮细胞和间质干细胞被认为是CAFs的主要来源.本文对CAFs的来源、分子机制和可能的潜在治疗靶作一综述.

关 键 词:肿瘤相关成纤维细胞  正常成纤维细胞  上皮间质转化  内皮间质转化  间质干细胞  

The origin of carcinoma-associated fibroblasts and its molecular mechanisms
Institution:ZHANG Hui , FAN Yue-zu, WANG Jin-si , LIN Meng-bo( 1. Department of Surgical Oncology , Fujian Provincial Hospital, Fuzhou 35001, China ; 2. Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China)
Abstract:Carcinoma-associated fibroblasts (CAFs) have not only been showed to play a crucial role in growth, progression and metastasis of tumors but also in the deposition of extracellular matrix (ECM). The normal fibroblasts, epithelial cells, endothelial cells and mesenchymal stem cells (MSCs) are recognized as the main source of CAFs. This paper aims to review the recent advances at the origin of the CAFs and its molecular mechanisms and possibility as potential therapeutic targets.
Keywords:Carcinoma-associated fibroblasts  Normal fibroblasts  Epithelial-to-mesenchymal transition  Endothelial to mesenchymal transition  Mesenchymal stem cell  Cancer
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