巴豆不同给药方式对荷瘤小鼠的影响

目的观察巴豆不同给药方式对荷瘤小鼠的影响。方法采用Lewis肺癌皮下移植模型和4T1乳腺癌肺转移模型观察巴豆不同给药方式对荷瘤小鼠的影响。结果在Lewis肺癌皮下移植模型中,巴豆霜灌胃有抑制肿瘤生长作用,同浓度巴豆水煎液灌胃对肿瘤生长抑制作用不明显,2种给药途径均能升高荷瘤小鼠脾脏指数,在4T1乳腺癌肺转移模型中,巴豆霜和巴豆水煎液灌胃能有效抑制肿瘤转移,有降低荷瘤小鼠碳粒廓清能力的趋势,不影响荷瘤小鼠脾脏指数。荷瘤小鼠血清抗氧化能力检测中,巴豆水煎液灌胃增加SOD和GSH-PX酶活性,巴豆霜却降低二者活性。结论巴豆给药方式影响其抗肿瘤活性,抗肿瘤作用与其免疫调节和抗氧化作用无关。

Effect of croton given by different way on mice bearing tumor

Objective To observe the effect of croton given by different way on mice bearing tumor.Methods Subcutaneous transplanted model of the lewis lung cancer and lung metastatic model of 4T1 mammary cancer were used to investigate effect of croton given by different way on mice bearing tumor.Results In subcutaneous transplanted model of the lewis lung cancer,defatted croton seed powder(DCSP) ig inhibited tumor growth whereas the same dose of croton decoction(CD) did not so.However,both of them could increase spleen index of mice.In lung metastatic model of 4T1 mammary cancer,DCSP ig could effectively suppress tumor metastasis,reduce charcoal particles clearance,but had no effect on spleen index.Antioxidant enzymes assays showed that CD could promote SOD and GSH-PX activity but DCSP suppressed them.Conclusion The different way of croton given influences its anti-tumor effect which isn’t associated with immune function and anti-oxidation.