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支架置入对ACS患者外周血EPCs数量和血清G-CSF浓度的影响
引用本文:张金盈,张力,王永奎,厉菁,梁莹.支架置入对ACS患者外周血EPCs数量和血清G-CSF浓度的影响[J].河南大学学报(医学版),2008,27(3).
作者姓名:张金盈  张力  王永奎  厉菁  梁莹
作者单位:郑州大学第一附属医院,心血管内科,河南,郑州,450052
摘    要:目的:观察支架置入术对急性冠脉综合征(ACS)患者外周血内皮祖细胞(EPCs)数量和血清粒细胞集落刺激因子(G-CSF)浓度的影响及意义。方法:32例行冠状动脉支架置入术的ACS患者根据不同临床类型分为:ST段抬高ACS急诊PCI组(n=7)和非ST段抬高ACS包括14例非ST抬高心肌梗死(NSTEMI)和11例不稳定心绞痛(UAP)择期PCI组(n=25)],10例同期经冠状动脉造影(CAG)证实无冠状动脉病变者作为对照组(n=10)。分别于术中和术后3 d抽取外周血进行EPCs的分离培养,同时分离血清以备G-CSF浓度检测。于第10 d对EPCs进行鉴定并于倒置相差显微镜下计数内皮祖细胞克隆形成单位(EPC-CFU)以评估外周血EPCs水平。G-CSF浓度检测采用酶联免疫吸附法(ELISA)。结果:①急诊PCI组术前外周血EPC-CFU数量稍高于择期PCI组,但无统计学意义(P>0.05),且均明显少于对照组(P<0.01)。急诊PCI组术前血清G-CSF明显高于择期PCI组,且均明显高于对照组。②急诊PCI组和择期PCI组术后外周血EPCs数量及血清G-CSF均有增高,但后者外周血EPCs数量增加幅度明显大于前者,对照组外周血EPCs数量及血清G-CSF改变无统计学意义(P>0.05)。③择期PCI组外周血EPCs增加数量与血清G-CSF改变相关(r=0.261,P=0.009),急诊组则无。结论:择期PCI患者术后外周血EPCs数量明显增加,且与血清G-CSF改变相关。AMI后急诊PCI患者术后血清G-CSF浓度明显升高但与外周血EPCs数量增加无明显相关。

关 键 词:经皮冠状动脉介入治疗  内皮祖细胞  粒细胞集落刺激因子

Effect of stent implantation on the number of circulating endothelial progenitor cells and plasma levels of granulocyte colony-stimulating factor in patients with acute coronary syndrome
ZHANG Jin-ying,ZHANG Li,WANG Yong-kui,LI Jing,LIANG Ying.Effect of stent implantation on the number of circulating endothelial progenitor cells and plasma levels of granulocyte colony-stimulating factor in patients with acute coronary syndrome[J].Journal of Henan University,2008,27(3).
Authors:ZHANG Jin-ying  ZHANG Li  WANG Yong-kui  LI Jing  LIANG Ying
Institution:ZHANG Jin-ying,ZHANG Li,WANG Yong-kui,LI Jing,LIANG Ying(Department of Cardiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
Abstract:Objective: To investigate the effect of stent implantation on the number of circulating endothelial progenitor cells(EPCs) and plasma levels of granulocyte colony-stimulating factor(G-CSF) in patients with acute coronary syndrome(ACS).Methods: 32 patients undergone coronary stenting ACS were divided into three groups: 7 patients with ST-elevation ACS were given urgent PCI(n=7);25 non-ST-elevation ACS received elective PCI(n=25),including 14 non-ST-elevation myocardial infarction(NSTEMI) and 11 unstable angi...
Keywords:Stent implantation  Endothelial progenitor cells  Granulocyte colony-stimulating factor  
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