| 银杏内酯B对AD模型大鼠学习记忆的影响 |
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| 引用本文： | 陈明亮,葛振英.银杏内酯B对AD模型大鼠学习记忆的影响[J].河南大学学报(医学版),2007,26(3):23-24. |
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| 作者姓名： | 陈明亮 葛振英 |
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| 作者单位： | 1. 河南大学医学院,生理学教研室,河南,开封,475004
2. 河南大学医学院,生物化学教研室,河南,开封,475004 |
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| 摘 要： | 目的:观察银杏内酯B对AD模型大鼠学习记忆的影响。方法:采用IBO损毁大鼠双侧Meynert基底核(NBM),建立AD动物模型,治疗组用不同剂量的银杏内酯B连续腹腔注射20 d,做跳台实验和Y迷宫实验,测试大鼠的学习记忆能力。结果:银杏内酯B治疗组较模型组学习记忆能力显著增强(P<0.01或P<0.05)。结论:银杏内酯B可提高AD模型大鼠的学习记忆能力。
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| 关 键 词： | 银杏内酯B 阿尔茨海默病 学习记忆 |
| 文章编号： | 1672-7606（2007）03-0023-02 |
| 修稿时间： | 2007-05-30 |
Effects of Ginkgolide B on the learning and memory ability of the model rats of Alzheimer's disease |
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| CHEN Ming-liang,GE Zhen-ying.Effects of Ginkgolide B on the learning and memory ability of the model rats of Alzheimer''''s disease[J].Journal of Henan University,2007,26(3):23-24. |
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| Authors: | CHEN Ming-liang GE Zhen-ying |
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| Institution: | Medical College of Henan University, Henan Kaifeng 475004, China |
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| Abstract: | Objective: To test the effects of ginkgolide B(GB) on learning and memory ability of Alzheimer′s disease(AD) model rats.Methods: AD animal model was established by microinjecting IBO(5 μg) into bilateral NBM of rat to damage them.GB at different concentrations was injected intraperitioneally in the GB rats for 20 days.20 days later,the learning and memory ability were tested using jumping table experiment and Y-maze experiment.Results: Compared with model group,the learning and memory abilities of GB groups were significantly improved.(P<0.01 or P<0.05).Conclusion: Ginkgolide B can improve the learning and memory ability of the model rats of Alzheimer′s disease. |
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| Keywords: | Ginkgolide B Alzheimer′s disease Learning and memory abilities |
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