| 疏风宣肺解毒方对豚鼠止咳作用及其机理的研究 |
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| 引用本文： | 张东坡,刘必旺,赵俊云,杨向竹,赵换,程生辉,朱冰清,徐荣芳,刘亚明. 疏风宣肺解毒方对豚鼠止咳作用及其机理的研究[J]. 山西中医学院学报, 2012, 13(2): 13-14,17 |
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| 作者姓名： | 张东坡 刘必旺 赵俊云 杨向竹 赵换 程生辉 朱冰清 徐荣芳 刘亚明 |
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| 作者单位： | 1. 山西中医学院,山西太原,030024
2. 北京中医药大学,北京,100029 |
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| 基金项目： | 国家“十一五”科技攻关计划资助项目(2007BAI07A02);山西省科技攻关项目(20090312020-3) |
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| 摘 要： | 目的:观察疏风宣肺解毒方的止咳作用,并分析探讨其作用机理。方法:使用豚鼠枸橼酸致咳法,观察疏风宣肺解毒方的止咳作用,并检测豚鼠肺组织中的SOD、MDA和IL-2因子,观察其对气管平滑肌的影响。结果:疏风宣肺解毒方的大、中剂量组与空白对照组相比,豚鼠的咳嗽潜伏期显著延长,咳嗽次数明显减少(P<0.05),疏风宣肺解毒方并能提高肺组织SOD、IL-2含量,降低MDA含量,其解痉率与空白对照组相比差异均有统计学意义(P<0.01)。结论:疏风宣肺解毒方具有较好的止咳作用,其机理可能通过影响SOD、MDA应激反应指标和IL-2炎症因子,并解除气管平滑肌痉挛而发挥止咳作用。
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| 关 键 词： | 疏风宣肺解毒方 豚鼠 止咳 |
Experimental Study on Cough-Relieving Effect and Mechanism of Shufeng Xuanfei Jiedu Decoction in Guinea Pig |
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| Zhang Dongpo , Liu Biwang , Zhao Junyun , Yang Xiangzhu , Zhao Huan , Cheng Shenghui , Zhu Bingqing , Xu Rongfang , Liu Yaming. Experimental Study on Cough-Relieving Effect and Mechanism of Shufeng Xuanfei Jiedu Decoction in Guinea Pig[J]. Journal of Shanxi College of Traditional Chinese Medicine, 2012, 13(2): 13-14,17 |
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| Authors: | Zhang Dongpo Liu Biwang Zhao Junyun Yang Xiangzhu Zhao Huan Cheng Shenghui Zhu Bingqing Xu Rongfang Liu Yaming |
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| Affiliation: | 1(1.Shanxi College of TCM,Taiyuan Shanxi 030024;2.Beijing University of TCM,Beijing 100029) |
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| Abstract: | Objective:To observe cough-relieving effects of Shufeng Xuanfei Jiedu decoction and analyze its mechanism.Methods:Cough-relieving effect of Shufeng Xuanfei Jiedu decoction on cough models of guinea pigs induced by citric acid was observed.Content of SOD,MDA and IL-2 in lung tissue was detected.Results:Compared with blank control group,incubation period for cough was prolonged,frequency of cough was reduced in Shufeng Xuanfei Jiedu decoction high and medium-dose group(P<0.05).Shufeng Xuanfei Jiedu decoction can improve the content of SOD and IL-2,decreased content of MDA in lung tissue.The rate of spasm was higher in Shufeng Xuanfei Jiedu decoction groups than that in blank control group(P<0.01).Conclusion:Shufeng Xuanfei Jiedu decoction has cough-relieving effect.Its mechanism may be related to its influence on content of SOD,MDA and IL-2 in lung tissue and spasmolysis effect. |
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| Keywords: | Shufeng Xuanfei Jiedu decoction guinea pig cough-relieving |
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