| 复方斑蝥胶囊体内外抗肿瘤作用的实验研究 |
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| 引用本文： | 张蕻,梁小军,朴晋华,张丽.复方斑蝥胶囊体内外抗肿瘤作用的实验研究[J].山西中医学院学报,2003,4(2):17-19. |
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| 作者姓名： | 张蕻 梁小军 朴晋华 张丽 |
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| 作者单位： | 1. 山西省药品检验所,山西,太原,030001
2. 山西省太原晋阳制药厂,山西,太原,030031 |
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| 摘 要： | 目的:通过体内外抗肿瘤实验观察复方斑蝥胶囊的抗肿瘤作用。方法:建立小鼠移植性肝癌(H_(22))和白血病(L_(1210))荷瘤动物模型,观察药物对荷瘤动物的抑瘤作用和生命延长作用,对环磷酰胺(Cy)的协同抑瘤作用;采用染料排斥法检测药物在不同浓度及不同作用时间下对靶细胞的杀伤作用,测出其半数杀伤浓度(IC_(50))。结果:复方斑蝥胶囊对H_(22)可产生显著的抑瘤作用;高剂量可明显增加环磷酰胺的抗癌效果,但对L_(1210)荷瘤动物的生存时间无显著延长。体外对H_(22)及L_(1210)的IC_(50)分别为(21.83±6.14)μg·ml~(-1)和(100.23±30.3)μg·ml~(-1)。结论:复方斑蝥胶囊在体内及体外均对H_(22)表现出明显的抑瘤作用,对L_(1210)作用不明显。
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| 关 键 词： | 复方斑蝥整胶囊 抗癌作用 小鼠 移植性肿瘤 H_(22) |
| 文章编号： | 1671-0258(2003)02-0017-03 |
| 修稿时间： | 2003年2月5日 |
Antineoplastic Studies of Compound Mylabris Capsules |
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| Zhang Hong,Liang Xiaojun,Pu Jinghua et al..Antineoplastic Studies of Compound Mylabris Capsules[J].Journal of Shanxi College of Traditional Chinese Medicine,2003,4(2):17-19. |
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| Authors: | Zhang Hong Liang Xiaojun Pu Jinghua |
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| Abstract: | Objective:To observe the antimeoplastic activity of compound mylabris capsules (CMC) in vitro and in vivo experiments. Methods: Tumor - bearing mouse models were set up by transplanting hepatoma (H22) and leukemia (L1210) ,then observing the CMC' s tumorostatic action and life -prolonging effect on the mice, as well as its synergism to Cy,determining CMC's tumoricidal power on the target cells in different levels and times, measuring its median inhibitory concentration (IC50). Results: CMC showed a marked tumorostatic effect on H22; Higher dose obviously strengthened Cy' s anticancer action, but did not markedly prolong the life of Lmo -bearing mice; in vitro test showes CMC's IC50 on H22 and Lmo was (21. 93±6. 14)μg·ml-1 and (100. 23±30. 3)μg·ml-1 respectively. Conclusion: Compound mylabris capsules exerts a marked tumorostatic effect on H22 in vitro and in vivo, but the effect is not clearly seen on Lmo. |
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| Keywords: | compound mylabris capsules antineoplastic effect mice transplantation tumor H22 |
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