抗风湿颗粒抗炎镇痛作用的实验研究

目的:观察抗风湿颗粒对大鼠急性炎症模型及小鼠疼痛模型的治疗作用。方法:实验一:32只SD大鼠随机分为4组,A模型组,B痹颗粒组,C抗风湿颗粒小剂量组,D抗风湿颗粒大剂量组;分别灌服相应药物1w后,琼脂造模,成功后,测量大鼠致炎足肿胀率及炎性组织前列腺素(PGE2)含量。实验二:120只小鼠,随机分为3大组,每大组40只,每大组再分4小组,每小组10只,随机分为A模型组,B痹颗粒组,C抗风湿颗粒小剂量组,D抗风湿颗粒大剂量组;灌服相应药物2w后,通过扭体法、热板法、压尾法观察其镇痛作用。结果:抗风湿颗粒有良好的抗炎镇痛作用,并可明显降低炎性组织PGE2含量。结论:抗风湿颗粒具有较强的抗炎镇痛作用。

Experimental Study on the Inhibiting Acute Inflammation and Relieving Pain of Kangfengshi Granule

Objective:Study on pharmacodynamics of Kangfengshi granule to acute inflammation rat and pain relieving function on mice.Method:Experiment one:32 SD rats were divided into 4 groups at random:(A)model group(B)Wang Bi group(C)Kangfengshi small dosage group(D)Kangfengshi big dosage group.Different drugs were given accordingly for one week.After acute inflammation model were made successfully, swelling ratio of right posterior claw and the PGE2 in inflammation tissue were tested.Experiment two:120 mice were divided into 3 big groups at random.Then every big group were divided into 4 groups at random:(A)model group (B)Wang Bi group (C)Kangfengshi small dosage group (D)Kangfengshi big dosage group.Mice were fed one week and were given the drug accordingly for two weeks.Then body twist reaction to hot plate tail pressing was observed.Results:Kangfengshi granule can inhibit acute inflammation and relieve pain effectively,it can also reduce PGE2 in inflammation tissue.Conclusion:Kangfengshi granule is effective on inhibiting acute inflammation and relieving pain.