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| 桑麻合剂提取纯化工艺研究 | |
| 引用本文： | 邱建永,王洛临,李智勇,张建军,许曼娇. 桑麻合剂提取纯化工艺研究[J]. 中国医药导报, 2012, 9(14): 129-130,135 |
| 作者姓名： | 邱建永 王洛临 李智勇 张建军 许曼娇 |
| 作者单位： | 1. 广东省第二中医院药剂科,广东广州,510095 2. 广东省中医研究所制剂研究室,广东广州,510095 3. 广东省第二中医院检验科,广东广州,510095 |
| 摘 要： | 目的研究桑麻合剂最佳提取纯化工艺。方法以总黄酮含量为指标,采用正交设计法,对料液比、提取时间、提取次数进行优化;采用单因素筛选法,对浓缩液的相对密度和药液含醇量进行优化。结果优选的水提取工艺条件为加水提取3次,料液比1∶8,提取1 h,乙醇沉淀工艺条件为浓缩液相对密度为1.05~1.10（60℃）,药液含醇量为70%。结论最佳工艺组合试验证实,该组合工艺条件较为可行、可靠。 |
| 关 键 词： | 总黄酮 提取工艺 纯化工艺 正交设计 单因素筛选 |
Study on Process of Sangma Mixture extraction and purification |
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| QIU Jianyong , WANG Luolin , LI Zhiyong , ZHANG Jianjun , XU Manjiao. Study on Process of Sangma Mixture extraction and purification[J]. China Medical Herald, 2012, 9(14): 129-130,135 | |
| Authors: | QIU Jianyong WANG Luolin LI Zhiyong ZHANG Jianjun XU Manjiao |
| Affiliation: | 1.Department of Pharmacy,the Second Chinese Medicine Hospital,Guangdong Province,Guangzhou 510095,China;2.Laboratory of Preparations,the Institute of Traditional Chinese Medicine,Guangdong Province,Guangzhou 510095,China;3.Department of Laboratory Medicine,the Second Chinese Medicine Hospital,Guangdong Province,Guangzhou 510095,China |
| Abstract: | Objective To explore the technology of Sangma Mixture extraction and purification.Methods Orthogonal design method was employed to optimize solid-liquid ratio,extraction time and extraction number with total flavonoid content as an indicator;single factor screening method was employed to optimize the relative density and alcohol content of the liquid medicine.Results The optimal water extraction process consisted of three times of extraction,a solid-liquid ratio of 1∶8 and 1 hour of extraction.The optimal ethanol precipitation process consisted of a relative density of 1.05-1.10(60℃) and alcohol content of 70%.Conclusion It is confirmed in the best combination test that the aforementioned process is feasible and reliable. |
| Keywords: | Total flavonoid Extraction process Purification process Orthogonal design Single factor screening |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |