母妊娠高血压综合征对早产儿血清皮质醇水平的影响及意义

目的探讨妊娠高血压综合征（简称妊高征）对早产儿血清皮质醇水平的影响及临床意义。方法对妊高征母亲所生早产儿141例（妊高征早产儿组）及特发性早产儿89例（对照组），于出生6h内、7日龄取静脉血，测定皮质醇水平，进行临床研究。结果生后6h内妊高征早产儿组血清皮质醇含量高于对照组，差异有统计学意义（P〈0．05）；7日龄妊高征早产儿组血清皮质醇含量稍高于对照组，但差异无统计学意义（P〉0．05）。结论妊高征对早产儿内分泌有影响，可引起早产儿皮质醇水平早期明显增高．提示其为妊高征早产儿较其他同胎龄早产儿较少发生呼吸窘迫综合征的重要机制之一；而妊高征早产儿皮质醇水平后期下降明显，影响围生儿质量。

Influence and significance of female pregnancy-induced hypertension on serum cortisol levels in preterm neonates

Objective To investigate the effect and clinical significance of pregnancy-induced hypertension on serum cortisol in preterm neonates. Methods 141 cases of premature infants born by pregnancy-induced hypertension mother （pregnancy-induced hypertension preterm neonates group） and 89 cases of idiopathic preterm infants （control group） were selected. Their venous blood was collected at 6 h and 7 d after born, then the cortisol levels were detected. Re- suits Serum cortisol levels at 6 h after born in the pregnancy-induced hypertension preterm neonates group were higher than those in the control group, there were significant differences between the two groups （P 〈 0.05）. Serum cortisol levels at 7 days after born in the pregnancy-induced hypertension preterm neonates group were little higher than those in the control group, but the two groups had no difference （P 〉 0.05）. Conclusion Pregnancy-induced hypertension can effect premature endocrine caused cortisol levels early significantly increased, this indicates that its one of the most important mechanisms of premature infants born by pregnancy-induced hypertension mother have less incidence of respiratory distress syndrome than other premature infants with gestational age, then the cortisol levels decreased in later stage can effect the quality of perinatal infant.