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维生素D受体基因、胃蛋白酶原C基因及TP53基因多态性与乳腺癌相关研究
引用本文:张海超,刘德权,王茂华,王建逵,梁英,叶挺,程思俊,张卓尼.维生素D受体基因、胃蛋白酶原C基因及TP53基因多态性与乳腺癌相关研究[J].中国医药导报,2011,8(3):9-10.
作者姓名:张海超  刘德权  王茂华  王建逵  梁英  叶挺  程思俊  张卓尼
作者单位:昆明医学院第三附属医院,云南昆明,650106
基金项目:2009年云南省社会发展科技计划(应用基础研究自筹经费)项目(2009ZC118M)
摘    要:乳腺癌的发病往往是外界各种不良因素及个体基因长期共同作用的结果,在众多因素中基因多态性是造成个体差异非常重要的一方面。通过国内外的病例对照研究我们发现维生素D受体基因、胃蛋白酶原C基因及TP53基因多态性与乳腺癌相关研究是目前国外的研究热点。通过对维生素D受体基因、胃蛋白酶原C基因及TP53基因多态性的研究可使我们进一步了解乳腺癌的病因。

关 键 词:基西多态性  乳腺癌  维生素D受体基因  胃蛋白酶原C基因  TP53基因

Study on associations of genetic polymorphisms of vitamin D receptor,pepsinogen C and Tp53 with the risk of breast cancer
ZHANG Haichao,LIU Dequan,WANG Maohua,WANG Jiankui,LIANG Ying,YE Ting,CHENG Sijun,ZHANG Zhuoni.Study on associations of genetic polymorphisms of vitamin D receptor,pepsinogen C and Tp53 with the risk of breast cancer[J].China Medical Herald,2011,8(3):9-10.
Authors:ZHANG Haichao  LIU Dequan  WANG Maohua  WANG Jiankui  LIANG Ying  YE Ting  CHENG Sijun  ZHANG Zhuoni
Institution:ZHANG Haichao,LIU Dequan,WANG Maohua,WANG Jiankui,LIANG Ying,YE Ting,CHENG Sijun,ZHANG Zhuoni(The Third Affiliated Hospital of Kunming Medical College,Kunming 650106,China)
Abstract:Breast carcinoma is a multifactor disorder,that is thought to result from an interaction between genetic background and environmental factors,among the many factors contributing to the individual difference,gene polymorphism is a matter of special importance.With the present situation and development of study of gene polymorphism,we find that the case-control study on the associations of genetic polymorphisms of vitamin D receptor,pepsinogen C and TP53 with the risk of breast cancer,which is becoming a hot ...
Keywords:Gene polymorphism  Breast cancer  Vitamin D receptor gene  Pepsinogen C gene  TP53 gene  
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