沙美特罗替卡松粉剂吸入治疗慢性阻塞性肺疾病急性加重期临床疗效观察

目的：观察沙美特罗替卡松粉剂吸入用于治疗慢性阻塞性肺疾病急性加重期（AECOPD）的疗效。方法：将187例住院AECOPD患者随机分为沙美特罗/替卡松粉剂吸入组、辅舒酮气雾剂吸入组及硫酸沙丁胺醇气雾剂吸入组,对比三组在治疗前后不同时期FEV1、FEV1/FVC、FEV1占预计值比及临床症状改善情况。结果：使用舒利迭组患者早期肺功能即有明显改善,随着使用时间的延长,肺功能逐渐稳定提高;使用辅舒酮组肺功能亦有改善,但其起效时间缓慢;使用硫酸沙丁胺醇组起效快,但随着使用时间的延长,效果反而下降。结论：沙美特罗替卡松粉剂吸入用于治疗AECOPD起效快,能持续改善肺功能及患者生活质量,是一种有效的临床手段。

Clinical observation of the efficacy of inhaling Salmeterol and Fluticasone Powder in the treatment of chronic obstructive pulmonary disease with acute exacerbation

Objective：To observe the efficacy of inhaling Salmeterol and Fluticasone Powder in the treatment of chronic obstructive pulmonary disease with acute exacerbation（AECOPD）.Methods：187 hospitalized patients with AECOPD were randomly divided into three groups by the drug of inhalation： the Salmetero/Fluticasone Powder inhalation group,Flixotide aerosol inhalation and aerosol inhalation of Salbutamol Sulfate group.FEV1,FEV1/FVC,FEV1 percentage of predicted value and clinical symptoms improvement were compared before and after treatment.Results：The lung function improved significantly in early time and increased steadily with long-term use for patients treated with Seretide;the lung function also improved for patients treated with Flixotide,but it took effects slowly;the lung function of Salbutamol Sulfate group improved rapidly,but the efficacy could not sustain with the time.Conclusion：The inhalation of Salmeterol and Fluticasone Powder is an effective in treatment of AECOPD,which takes effect rapidly and can improve the lung function as well as the quality of life continuously.