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| Fascin和MVD的表达与垂体腺瘤侵袭性的关系 | |
| 引用本文： | 宋志远,仝海波,郑绘霞,贾睿超,任斌,郝解贺. Fascin和MVD的表达与垂体腺瘤侵袭性的关系[J]. 中国医药导报, 2011, 8(1): 23-26 |
| 作者姓名： | 宋志远 仝海波 郑绘霞 贾睿超 任斌 郝解贺 |
| 作者单位： | 1. 山西医科大学,山西太原,030001 2. 山西医科大学第一医院神经外科,山西太原,030001 3. 山西医科大学第一医院病理科,山西太原,030001 |
| 摘 要： | 目的：检测Fascin及MVD在侵袭性和非侵袭性垂体腺瘤中的表达，探讨其与垂体腺瘤侵袭性的关系及它们之间的相关性。方法：采用免疫组织化学Envision法检测24例侵袭性和21例非侵袭性垂体腺瘤组织中Fascin蛋白表达水平，计数CD34标记的肿瘤微血管密度（MVD）。统计学分析两组之间Fasicn蛋白的表达、MVD计数的差异，以及侵袭性垂体腺瘤中Fascin的表达与MVD计数之间的相关关系。结果：侵袭性垂体腺瘤组Fascin蛋白表达及MVD计数均较非侵袭性垂体腺瘤组增高。侵袭组中Fascin蛋白表达与MVD计数呈正相关关系。结论：侵袭性垂体腺瘤的生物学行为与Fascin的高表达以及血管生成密切相关．二者可作为判断垂体瘤侵袭性及预后的生物学指标。 |
| 关 键 词： | 垂体腺瘤 Fascin MVD 侵袭性 |
The relationship of expression of Fascin and MVD and invasiveness of pituitary adenoma |
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| SONG Zhiyuan,TONG Haibo,ZHENG Huixia,JIA Ruichao,REN Bin,HAO Jiehe. The relationship of expression of Fascin and MVD and invasiveness of pituitary adenoma[J]. China Medical Herald, 2011, 8(1): 23-26 | |
| Authors: | SONG Zhiyuan TONG Haibo ZHENG Huixia JIA Ruichao REN Bin HAO Jiehe |
| Affiliation: | SONG Zhiyuan1,TONG Haibo2,ZHENG Huixia3,JIA Ruichao1,REN Bin1,HAO Jiehe2(1.Shanxi Medical University,Taiyuan 030001,China,2.Department of Neurosurgery,the First Hospital of Shanxi Medical University,3.Department of Pathology,China) |
| Abstract: | Objective: To investigate the expression of Fascin and MVD in patients with invasive and non-invasive pituitary adenomas,and to evaluate the relationship between the expression of Fascin,CD34 and the invasion of pituitary adenomas,and to analyze the correlation between Fascin and MVD in invasive pituitary adenomas.Methods: The expressions of Fascin and CD34 were detected in 24 invasive pituitary adenomas and 21 non-invasive pituitary adenomas by using immunohistochemical Envision assay.And MVD signed by CD3... |
| Keywords: | Pituitary adenoma Fascin MVD Invasiveness |
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