可博利口服液澄清工艺研究

目的：研究可博利口服液的澄清工艺。方法：以两种不同工艺配制制剂,比较总固体物含量,并采用正交试验法,以冬虫夏草多糖含量及总固体物含量为指标,优选澄清工艺,再进行稳定性考察的比较。结果：壳聚糖澄清工艺的总固体物含量比原工艺高14.7%,优选的澄清工艺为药液温度50℃、药液浓度（g∶ml）=1∶4、1%壳聚糖的用量为3%（W/W）。结论：本实验简化了壳聚糖澄清工艺,使有效成分的总保留量得到提高,且制剂稳定。

Study on clarification process of Keboli Oral Solution

Objective：To study the clarification process of Keboli Oral Solution.Methods：Two processes were applied,comparing the extract percents.The orthogonal design test was used to obtain the optimum preparation process with cordycepin polysaccharide as marker.Stability of the two preparations were compared.Results：Extract percent of chitosan flocculation was 14.7% higher than the original process.The optimized conditions were that 3%（W/W）chitoson flocculating agent was added at 50℃ with durg solution concentration of 1∶4（g∶ml）.Conclusion：The optimum process is simple,can reserve more effective components and has a good stability.