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青春期多囊卵巢综合征患者内分泌、代谢紊乱特征分析
引用本文:谭庆玲.青春期多囊卵巢综合征患者内分泌、代谢紊乱特征分析[J].中国医药导报,2011,8(36):42-44.
作者姓名:谭庆玲
作者单位:湖北民族学院附属医院,湖北恩施,445000
摘    要:目的:探讨青春期多囊卵巢综合征(PCOS)患者的内分泌及代谢紊乱特征。方法:青春期PCOS患者87例(PCOS组),其中52例体重指数(BMI)≥25 kg/m2或腰臀比(WHR)≥0.85者为肥胖组(OB-PCOS);35例BMI〈25 kg/m2,WHR〈0.85者为非肥胖组(NOB-PCOS)。正常对照组102例,为月经正常的中学生,同样分为肥胖组(OB-CON)22例,非肥胖组(NOB-CON)80例。所有对象均测定睾酮(T)、促黄体生成素(LH)、泌乳素(PRL)、促黄体生成素/促卵泡激素(LH/FSH)比值、空腹胰岛素及稳态模型指数(HOMA-IR)、空腹血糖、血脂,测定人BMI及WHR,记录月经史。结果:对照组初潮年龄为(13.0±1.3)岁,96%在初潮后2年内建立规律月经。PCOS组初潮年龄为(12.0±1.5)岁,86%的患者在2年内未能建立规律月经。PCOS组肥胖发生率显著高于对照组(P〈0.01)。PCOS组血清T、LH、PRL、LH/FSH比值、空腹FINS、HOMA-IR、TC、TG及BMI、WHR均显著高于对照组(P〈0.01),并且OB-PCOS组高于NOB-PCOS(P〈0.05)。96.3%PCOS患者卵巢超声提示多囊样改变。结论:青春期多囊卵巢综合征的特征为肥胖,月经初潮提前及持续月经不调,存在胰岛素抵抗,卵巢多囊性增大。

关 键 词:青春期  多囊卵巢综合征  内分泌  代谢

Analysis of the character of reproductive endocrine and metabolic abnormalities in adolescent girls with polycystic ovary syndrome
TAN Qingling.Analysis of the character of reproductive endocrine and metabolic abnormalities in adolescent girls with polycystic ovary syndrome[J].China Medical Herald,2011,8(36):42-44.
Authors:TAN Qingling
Institution:TAN Qingling Affiliated Hospital to Hubei University for Nationalities,Hubei Province,Enshi 445000,China
Abstract:Objective:To investigate the character of reproductive endocrine and metabolic abnormalities in adolescent girls with polycystic ovary syndrome(PCOS).Methods:87 adolescent girls with PCOS were selected as PCOS group.52 girls with BMI≥25 kg/m2,or WHR≥0.85 were divided into obese group(OB-PCOS) and the other 35 cases were selected as non-obese group(NOB-PCOS).A total of 102 adolescent girls with normal menstruation were selected,22 obese(OB-CON) and 80 non-obese(NOB-CON).T,LH,PRL,LH/FSH,HOMA-IR,FBG,TG,TC,BMI and WHR were observed and menstrual history was recorded.Results:Menarche age was significantly earlier in adolescent PCOS(12.0±1.5) years than that in control group(13.0±1.3) years.The incidence of obesity was significantly higher in PCOS group than that in control group(P〈0.01).T,LH,LH/FSH,FINS,HOMA-IR,TG,TC,BMI and WHR were significantly higher in PCOS group than those in control group(P〈0.01),and those in OB-PCOS were significantly higher than those in NOB-PCOS(P〈0.05).96.3%PCOS girls presented with an ultrasonic morphological evidence of polycystic ovarian.Conclusion:The features of adolescent PCOS are obesity,earlier onset of menarche and persistent menstrual disorder,insulin resistance,polycystic ovarian.
Keywords:Adolescence  Polycystic ovary syndrome  Endocrine  Metabolize  
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