| 美洛昔康醇质体凝胶的研制 |
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| 引用本文： | 杨羽行,刘小平. 美洛昔康醇质体凝胶的研制[J]. 中国医药导报, 2011, 8(35): 78-80 |
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| 作者姓名： | 杨羽行 刘小平 |
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| 作者单位： | 武汉理工大学化工学院制药工程系,湖北武汉,430070 |
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| 摘 要： | 目的：制备美洛昔康醇质体凝胶。方法：通过正交设计优选出美洛昔康醇质体的制备工艺,利用HPLC法测定包封率,并对其进行外观粒径评价,从而制备出凝胶剂。结果：制备的醇质体粒径分布均匀,平均粒径为16.95μm,包封率为74.70%。制得凝胶剂为半透明黏稠状胶体,平均含量为2.17 mg/10 g。结论：本实验制备工艺简单,制得的美洛昔康醇质体凝胶有很好的稳定性,具有较好的应用前景。
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| 关 键 词： | 美洛昔康 醇质体 醇质体凝胶 |
Preparation of Meloxicam Ethosomes Gel |
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| YANG Yuxing,LIU Xiaoping. Preparation of Meloxicam Ethosomes Gel[J]. China Medical Herald, 2011, 8(35): 78-80 |
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| Authors: | YANG Yuxing LIU Xiaoping |
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| Affiliation: | YANG Yuxing,LIU Xiaoping College of Chemical Engineering,Wuhan University of Technology,Hubei Province,Wuhan 430070,China |
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| Abstract: | Objective： To prepare Meloxicam Ethosomes Gel.Methods： The optimum preparation process of Meloxicam Ethosomes Gel was selected with orthogonal design.The rate of envelopment was determined by HPLC method.The shape,grainsize and its distribution of Meloxicam Ethosomes Gel were evaluated based on the Gel.Results： The prepared Ethosomes Gel with high encapsulation efficiency（74.70%） had narrow size distribution.The number of mean grain size was 16.95 μm.The Gel was translucent and ropy which was valued at 2.17 mg/10 g for its average content.Conclusion： The Meloxicam Ethosomes Gel with preferable stability is prepared with a uncomplicated technology.It is valuable with application prospect. |
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| Keywords: | Meloxicam Ethosomes Ethosomes Gel |
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