| 小细胞肺癌分子标志物PARP1的研究进展 |
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| 引用本文： | 王露,朱哲慧,陈思敏,赖仁胜. 小细胞肺癌分子标志物PARP1的研究进展[J]. 中国医药导报, 2012, 9(35): 66-68 |
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| 作者姓名： | 王露 朱哲慧 陈思敏 赖仁胜 |
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| 作者单位： | 王露 (江苏省中医院病理科,江苏南京,210000)；朱哲慧 (空降兵学院门诊部,广西桂林,541003)；陈思敏 (江苏省中医院病理科,江苏南京,210000)； 赖仁胜(江苏省中医院病理科,江苏南京,210000)； |
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| 基金项目： | 江苏省高校优势学科建设工程资助项目(012062003010) |
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| 摘 要： | 小细胞肺癌是一个侵袭性强的恶性肿瘤,其转移性和治疗效果均与非小细胞肺癌不同。肺癌的临床预后的改善,越来越多的与建立在致病机制基础上的分子标志物的靶向治疗有关。虽然已知小细胞肺癌有很多基因变异,但尚未明确某些分子靶向治疗能够延长小细胞肺癌的生存期。近年来,研究发现PARP1可以作为治疗小细胞肺癌患者的潜在靶点,小细胞肺癌对PARP抑制剂有显著的敏感性。本文主要就PARP1作为分子靶向治疗基因在小细胞肺癌中的研究进展进行详细总结。
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| 关 键 词： | PARP1 小细胞肺癌 分子靶向治疗 |
Research progress on PARP1 as a molecular target gene in the small cell lung cancer |
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| WANG Lu,ZHU Zhehui,CHEN Simin,LAI Rensheng. Research progress on PARP1 as a molecular target gene in the small cell lung cancer[J]. China Medical Herald, 2012, 9(35): 66-68 |
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| Authors: | WANG Lu ZHU Zhehui CHEN Simin LAI Rensheng |
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| Affiliation: | 1.Department of Pathology,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Jiangsu Province,Nanjing 210000,China;2.Outpatient Department,the Paratroopers College,Guangxi Zhuang Autonomous Region,Guilin 541003,China |
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| Abstract: | Small cell lung cancer（SCLC） is an aggressive malignancy distinct from non-small cell lung cancer（NSCLC） in its metastatic potential and treatment response.Improvement in the clinical outcome of lung cancer is more likely to be associated with the molecular targeted therapy based on its pathogenesis.Although several genomic aberrations have been identified,no molecularly targeted agents have prolonged survival in patients with SCLCs.Recently,PARP1 have been identified as a potential therapeutic target.SCLCs have been observed remarkably sensitivity to PARP inhibitors.This review will mainly make a conclusion on the research progress of PARP1 as a molecular targeted therapy gene in SCLCs. |
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| Keywords: | PARP1 SCLC Molecular targeted therapy |
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