泰乐菌素及其衍生物研究进展

泰乐菌素是目前国际上广泛使用的兽用抗生素,国外对泰乐菌素的研究一直没有停止过。目前国内外通过生物转化和化学合成的手段,生产出一系列泰乐菌素的衍生物。这些衍生物在药效上大大高于泰乐菌素,在药物残留方面比泰乐菌素表现出很大的优势,有逐渐取代泰乐菌素的趋势。本文综述了目前国际上各种泰乐菌素的衍生物的结构性质及合成方法,并重点介绍了运用生物转化法合成乙酰异戊酰泰乐菌素的研究进展,对了解和研究泰乐菌素衍生物,制备新一代的高效低毒抗生素具有指导意义。

Progress On The Studies of Tylosin and Derivate

Tylosin was a kind of widely used antibiotics in the world.And studying have never been ceased.A seriers of tylosin remnants were born by biotransformatin and chemical synthesis in the present.These substance will replace tylosin because of lower remnant and effective cure.The article reviewed the molecule structure ,the character and the synthesis method of tylosin and their remnants. And the method of Acetylisovalerytylosin biotransformation was presentation to the point. It offered a rich guiding significance to the study of tylosin remnant and the preparation of new generation antibiotics possessing highly active and low toxicity.