慢性肾功能衰竭动物模型研究进展

近年来，慢性肾功能衰竭（CRF）动物模型建立方法及评价指标不断完善，但仍存在一定的局限性。本文对近年来文献中建立CRF动物模型的操作方法、模型特点与临床运用进行归纳和总结，综述了CRF动物模型的研究进展，归纳出物理、化学、生物学三大类造模方法，为进一步规范动物模型的诊断标准，寻求统一、稳定、简便的动物模型提供依据。不同的CRF动物模型均有其各自的特点及运用范围，实际工作中应根据各自研究的侧重点来选用，以助于研究者更好地探讨肾脏病组织形态、生化指标的变化和临床表现的相互关系，阐述CRF的发病机制，筛选有效药物及阐明疗效机制。

Research progress of chronic renal failure animal models

In recent years, the modeling methods and evaluation indexes of chronic renal failure animal models are improving, but they are imperfect. The modeling methods, characters and clinical applications of chronic renal failure animal models from recent literatures are summarized; research progress of animal models is reviewed; the physical, chemical, biological molding methods are summed up in this paper. This article provides the basis for standardizing diagnostic criteria of models and seeking for unified, stable and convenient animal models. Different models have their respective advantages and disadvantages, so clinical workers should choose different animal models in base of the investigation of primary disease in order to help them discuss the relationship among renal pathology, biochemical criterion and clinical manifestation, expound pathogenesis of chronic renal failure and make a screen of effective drugs.