| Wnt信号通路成员APC蛋白在结直肠癌细胞黏附中的作用 |
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| 引用本文： | 余敏,李健宁.Wnt信号通路成员APC蛋白在结直肠癌细胞黏附中的作用[J].中国医药导报,2014(34):158-160. |
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| 作者姓名： | 余敏 李健宁 |
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| 作者单位： | 重庆市万盛经济开发区人民医院妇产科;山东省医学科学院附属医院麻醉手术室 |
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| 基金项目： | 山东省医学科学院院级科技计划青年基金项目（编号2013-45） |
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| 摘 要： | APC基因编码的APC蛋白是一个多功能抑制肿瘤的蛋白家族,其主要功能是通过下调胞浆内游离的β-连环蛋白（β-catenin）水平发挥肿瘤抑制功能,是Wnt信号通路关键的效应因子。已有研究证实,APC基因在细胞黏附、细胞迁移和染色体分离等基本细胞功能中发挥作用。近期的研究表明,APC蛋白在肠上皮细胞黏附过程中发挥重要的作用。现综述APC蛋白在结直肠癌细胞黏附过程中的作用机制。
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| 关 键 词： | Wnt信号通路 APC蛋白 结直肠癌 细胞黏附 |
The role of Wnt signalling pathway and its APC partner in colorectal cancer cellular adhesion |
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| Institution: | YU Min,LI Jianning (1.Department of Gynaecology, People＇s Hospital of Wansheng Economic Development District, Chongqing 400800, China; 2.Anesthesia Operating Room, the Affiliated Hospital of Shandong Academy of Medical Sciences, Shandong Province, Ji＇nan 250031, China) |
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| Abstract: | Adenomatous polyposis coli（APC） is an important tumor suppressor in the mammalian intestinal epitheli-um. It binds to beta-catenin and its role as a tumor suppressor depends predominantly on its ability to down-regulate soluble beta-catenin. Further studies have suggested that APC plays roles in several other fundamental cellular pro-cesses, including cell adhesion, migration, and chromosome segregation. Recently evidence points to a role for APC in intestinal epithelium cellular adhesion. This article systematic reviews the mechanism of APC protein in colorectal cancer cellular adhesion. |
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| Keywords: | Wnt signal pathway APC protein Colorectal cancer Cell adhesion |
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