| 人类巨细胞病地人胚肺细胞HOX基因表达的影响 |
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| 引用本文： | 陈利玉,王吉伟.人类巨细胞病地人胚肺细胞HOX基因表达的影响[J].湖南医科大学学报,2000,25(5):440-442. |
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| 作者姓名： | 陈利玉 王吉伟 |
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| 作者单位： | 微生物学教研室,长沙 |
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| 摘 要： | 应用半定量ＲＴ－ＰＣＲ技术研究人胚肺（ＨＥＬ）细胞ＨＯＸ基因的表达状态及人类巨细胞病毒（ＨＣＭＶ）对ＨＥＬ细胞ＨＯＸ基因表达的影响。结果发现：ＨＥＬ细胞表达ＨＯＸＢ７基因；ＨＣＭＶ感染后，其表达上调；用全反式维甲酸（ＡＴＲＡ）处理ＨＥＬ细胞，ＨＣＭＶ对ＨＯＸＢ７基因表达的上调作用更强。提示ＨＣＭＶ可能通过影响ＨＯＸＢ７基因的表达导致胚胎发育畸形。
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| 关 键 词： | 巨细胞病毒 HOX基因 人胚肺细胞 RT－PCR |
Influence of human cytomegalovirus infection on the expression of HOX genes in human embryo lung cells] |
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| L Y Chen,G Dai,G J Wu,J W Wang,M H Luo,S Z Chen.Influence of human cytomegalovirus infection on the expression of HOX genes in human embryo lung cells][J].Bulletin of Hunan Medical University,2000,25(5):440-442. |
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| Authors: | L Y Chen G Dai G J Wu J W Wang M H Luo S Z Chen |
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| Institution: | Department of Microbiology, Hunan Medical University, Changsha 410078. |
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| Abstract: | The expressions of HOX genes in human embryo lung (HEL) cells were detected with semi-quantitative RT-PCR method. The results were that HEL cells expressed HOXB7 gene and its expression increased after human cytomegalovirus (HCMV) infection. The level of expression reached maximum at 48 h after HCMV infection. Treated with all-trans retinoic acid (ATRA), the expression of HOXB7 in HEL cells infected by HCMV was significantly increased. The results suggest that the abnormal expression of HOX genes induced by HCMV might possibly play a role in virus-induced abnormal embryogenesis. |
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