| 多发性骨髓瘤的基因表达谱分析 |
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| 引用本文： | 石奕武,胡维新,汤立军,田菁燕,易伟峰,谭达人.多发性骨髓瘤的基因表达谱分析[J].湖南医科大学学报,2003,28(3):201-205. |
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| 作者姓名： | 石奕武 胡维新 汤立军 田菁燕 易伟峰 谭达人 |
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| 作者单位： | [1]中南大学湘雅医学院分子生物研究中心，长沙410078 [2]中南大学湘雅医院血液科，长沙410008 |
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| 摘 要： | 目的：研究MM患者与正常人骨髓基因的差异表达。方法：应用cDNA芯片技术对10例初诊多发性骨髓(MM)患者和10名正常骨髓的单个核细胞的mRNA进行检测。结果：在2048条基因中共发现差异表达基因566条。在MM中237条表达增加，329条表达降低。结论：MM的发生发展涉及多基因的改变，cDNA芯片技术可高效研究多个基因的表达水平。
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| 关 键 词： | 多发性骨髓瘤 基因表达谱 分析 cDNA芯片技术 骨髓基因 |
Gene expression profile changes in human multiple myeloma] |
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| Yi-wu Shi,Wei-xin Hu,Li-jun Tang.Gene expression profile changes in human multiple myeloma][J].Bulletin of Hunan Medical University,2003,28(3):201-205. |
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| Authors: | Yi-wu Shi Wei-xin Hu Li-jun Tang |
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| Institution: | Molecular Biology Research Center, Xiangya School of Medicine, Central South University, Changsha 410078, China. |
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| Abstract: | OBJECTIVE: To determine the difference in gene expression between human multiple myeloma (MM) and normal bone marrow. METHODS: cDNA chip was used to detect the mRNA of mononuclear cell from 10 untreated MM patients and 10 cases of normal bone marrow. RESULTS: Of the 2,048 genes, we found 566 different expression genes, of which the expression of 237 genes was higher and 329 lower in MM than in the normal bone marrow. CONCLUSION: Many genes may be involved in the pathogenesis of MM. cDNA chip technology is an effective tool in the study of tumor related genes. |
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