葛根素对心力衰竭患者心功能及氧化型低密度脂蛋白的影响

目的：观察葛根素对慢性心力衰竭者心功能及氧化型低密度脂蛋白（ｏｘ－ＬＤＬ）的影响。方法：选择１９９７～１９９８的我科住院的７８例慢性心力衰竭患者，随机分为常规治疗组（简称常规组）和常规＋葛根素治疗组（简称葛根素组），所有病人均给予强心、利尿、扩张知管等常规治疗，葛根素组加用葛根素４００ｍｇ．ｄ＾－１，程为１０ｄ。结果：治疗后，两组病人临床心功能均有改善，但两组差异无显著性（Ｐ〉０．０５），葛根素

Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]

OBJECTIVE: To observe the effect of puerarin on heart function and serum oxidized-LDL(ox-LDL) in patients with chronic cardiac failure. METHODS: Seventy-eight patients with chronic cardiac failure were randomly divided into two groups, regular group (R) and regular + puerarin group (P). All patients in two groups received conventional treatment with inotropic agents, diuretic, and vasodilator, etc. The patients in the P group took puerarin 400 mg.d-1 for 10 days. RESULTS: After treatment, the clinical heart function of the patients in the two groups was improved, but there was no significant difference between them; the left ventricular ejection fraction (EF) of patients in the P group was higher than that in the R group(P < 0.05); and serum ox-LDL level was significantly decreased in the P group patients, but that was no change in the R group patients(P < 0.05). CONCLUSION: Puerarin may improve the clinical heart function, increase the left ventricular ejection, meanwhile, it may decrease the level of ox-LDL.