| 中药拮新康抗白血病细胞与免疫机能的研究 |
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| 引用本文： | 谢兆霞,秦群.中药拮新康抗白血病细胞与免疫机能的研究[J].湖南医科大学学报,1999,24(3):245-247. |
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| 作者姓名： | 谢兆霞 秦群 |
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| 作者单位： | [1]湖南医科大学附属湘雅医院血液科 [2]附属湘雅医院药剂科 |
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| 摘 要： | 采用中药制剂拮新就对３４例白血病患者的白血病细胞进行体外细胞毒性试验，试验显示：长春新碱＋拮新康组较长春新碱组细胞新毒性明显增加，其中２０例为难治与复发白血病患者对长春新碱已耐药，但加拮新康后细胞毒性作用增强；同时拮新康本身对白血细胞也有一定的抗肿瘤作用。采用环磷酰胺抑制小鼠免疫机能作实验模型，探讨“拮新康”对小鼠细胞免疫机能的影响，发现其对免疫损伤动物模型及正常动物的ＩＦＮｒ与ＮＫ活性水平较对照
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| 关 键 词： | 拮新康 白血病 小鼠 中医药疗法 免疫机能 |
Study on cytotoxicity to leukemia cell and enhancement of immunologic functions of jiexinkang] |
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| Z Xie,D Tan,J Xie,Q Qin,G Tan,P Xu.Study on cytotoxicity to leukemia cell and enhancement of immunologic functions of jiexinkang][J].Bulletin of Hunan Medical University,1999,24(3):245-247. |
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| Authors: | Z Xie D Tan J Xie Q Qin G Tan P Xu |
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| Institution: | Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008. |
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| Abstract: | Cytotoxicity to leukemia cell and enhancement of immunologic functions of jiexinkang (JXK, traditional Chinese medicine) were observed in 34 cases of leukemia in vitro. The results showed that the leukemia cytotoxicity in the group of vincristine combined with JXK was significantly higher than that in vincristine alone. It was also found among all the observed cases that 20 refractory or recurred patients resistant to vincristine showed an obvious intention of the anti-toxicity efficiency when JXK was added. Jiexinkang alone had anti-leukemia cell effect, too. We explored JXK effects on immunologic functions in mice, and found that IFNr and NK activities of normal and experimental model mice were significantly higher than those of control group(P < 0.01). The results indicate that JXK has an effect of anti-leukemia cell and may improve the cell-immunologic functions. |
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