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缺血预处理对肺保护的临床研究
引用本文:陈胜喜,李国虎.缺血预处理对肺保护的临床研究[J].湖南医科大学学报,1999,24(4):357-359.
作者姓名:陈胜喜  李国虎
摘    要:在常温下长时程阴断一侧肺动脉主干作肺叶切除病例20例,10例为预处理组,10例为对照组。结果提示:预处理组轿中降钙素基因相关肽(CGRP)、超氧化物歧化酶(SOD)及肺静脉氧分压(PpvO2)较对照组明显增加(P〈0.05),而血中丙二醛(MDA)含量及肺平均动脉压(MPAP)较对照明显降低(P〈0.05)。提示缺血预处理能减轻在体肺缺血再灌注损伤,其机制可能与内源性降钙素基因相关肽产生增加有关。

关 键 词:肺缺血  肺保护  缺血预处理  CGRP  SOD

Clinical research of ischemic preconditioning on lung protection]
S Chen,G Li,L Long.Clinical research of ischemic preconditioning on lung protection][J].Bulletin of Hunan Medical University,1999,24(4):357-359.
Authors:S Chen  G Li  L Long
Institution:Department of Cardiothoracic Surgery, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Abstract:Twenty patients, who only need to occlude main pulmonary artery underwent pulmonectomy, were randomized into two groups. Ten patients were treated with ischemic preconditioning(IP). Their main pulmonary artery was clamped for 10 minutes and released for 10 minutes(Group IP). Ten patients were not treated with ischemic preconditioning(Group C). The results showed that the content of calcitonin gene related peptide(CGRP) in Group IP was significantly higher than that in Group C after ischemic preconditioning. After lung reperfusion for 30 minutes, the value of superoxide dismutase and pulmonary vein blood oxygen tension in Group IP was significantly higher than that in Group C. It is evident that ischemic preconditioning could reduce normothermic human lung ischemia reperfusion injury. The possible mechanism is that ischemic preconditioning increases the production of endogenous CGRP.
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