| Combined Toxicity of Lidocaine and L-4-Thiazolidine Carboxylic Acid and Comparison of the Methods for Its Evaluation |
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| 作者姓名： | 杨晓敏 赵德化 盛宝恒 |
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| 作者单位： | Department of Pharmacology Fourth Military Medical College，Xi'an，Department of Pharmacology，Fourth Military Medical College，Xi'an，Department of Pharmacology，Fourth Military Medical College，Xi'an |
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| 摘 要： | The combined toxicity of L-4-thiazolidine carboxylic acid(T)andlidocaine was observed.LD_(50) values and their 95% fiducial limits of T andlidocaine were 144.5±8.8 and 36.3±3.4 mg/kg respectively when given intrave-nously alone.When 1/4,1/2 or 3/4 LD_(50) of T had been given intravenously 10 minbefore lidocaine was given intravenously,the combined LD_(50) values and 95%fiducial limits of T and lidocaine were respectively 45.5±3.9,47.8±4.9 and30.3±3.4 mg/kg.The combined toxicity of T and lidocaine was calculated by themethods of isobologram,Q_(50) and q”values.The results showed that when the dosewas lower than its 1/2 LD_(50),T could antagonize the toxicity of lidocaine,butwhen larger than its 1/2 LD_(50).it could synergize the toxicity of lidocaine.Theavailable field of Q_(50) and q”values were discussed in this paper.The resultsindicated that q”values were superior to Q_(50) values when they were used tocalculate the combined toxicity of the two drugs.
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Combined Toxicity of Lidocaine and L-4-Thiazolidine Carboxylic Acid and Comparison of the Methods for Its Evaluation |
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| Yang Xiaomin Zhao Dehua Sheng Baoheng.Combined Toxicity of Lidocaine and L-4-Thiazolidine Carboxylic Acid and Comparison of the Methods for Its Evaluation[J].Journal of Medical Colleges of PLA(China),1987(1). |
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| Authors: | Yang Xiaomin Zhao Dehua Sheng Baoheng |
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| Institution: | Yang Xiaomin Zhao Dehua Sheng Baoheng Department of Pharmacology,Fourth Military Medical College,Xi'an |
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| Abstract: | |
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| Keywords: | L-4-thiazolidine carboxylic acid lidocaine LD_(50) |
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